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Effipro Duo

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Fipronil + Pyriproxyfen · Virbac

5 forms: spot-on. In force in Georgia: 5 of 5 (veterinary register).

Forms and doses5 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
50 mg/60 mg, Spot-on · Cat 1–6 kg Cat 1–6 kg 1 pipette
For a cat weighing 1-6 kg apply one pipette of 0.5 ml per cat corresponding to the minimum recommended dose of 8.3 mg fipronil/kg b.w. and 10 mg pyriproxyfen/kg b.w. do not repeat the treatment at intervals of less than 4 weeks.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 50მგ/60მგ დასაწვეთებელი ხსნარი კატებისათვის
№ 76-11
Verified on: 15 Oct 2026
50 mg/60 mg, Spot-on · Cat 6–12 kg Cat 6–12 kg 2 pipettes
>6-12 kg 1 ml 100 [mg fipronil] 120 [mg pyriproxyfen] For a cat weighing more than 6 kg a recommended dose of 1 ml should be applied, which can be achieved by applying two 0.5 ml pipettes.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 50მგ/60მგ დასაწვეთებელი ხსნარი კატებისათვის
№ 76-11
Verified on: 15 Oct 2026
50 mg/60 mg, Spot-on · Dog Any weight Dog Any weight No dose for this species
This pipette is for cats. For dogs, use Effipro Duo 67/20, 134/40, 268/80, or 402/120.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 50მგ/60მგ დასაწვეთებელი ხსნარი კატებისათვის
№ 76-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effipro Duo 50 mg/60 mg, Spot-on

fipronil 50 mg + pyriproxyfen 60 mg, spot-on solution for cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.1/10
Very good
vetman assessment

Effipro Duo

50 mg/60 mg, fipronil 50 mg + pyriproxyfen 60 mg, spot-on solution for cats
Assessed clinical scopeCat · Full feline flea-centred label: flea treatment/prevention, 12-week inhibition of flea development, FAD strategy, and tick treatment when fleas are present or also require control · On the skin
Care settingOne exact species/weight-band pipette on intact dry skin after weighing and parasite assessment, with environmental flea control when needed
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 76-11 · Verified on 15 Oct 2026

A well-regulated flea-centred fixed combination with useful 12-week immature-stage control and labelled tick activity. It is a strong exact-form option when both components fit the clinical goal, but it is not a repellent and tick protection is not uniform across species.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia and the product line retains current UK regulatory records, exact official product information and a favourable fixed-combination assessment.

Clinical efficacy7.5/10

Regulatory studies and product-specific controlled or field data support adult-flea control, 12-week inhibition of flea development and labelled tick activity. Tick persistence is species-dependent and shorter in cats, while correct skin application and environmental pressure materially affect outcome.

Safety and tolerability8.0/10

Label-dose tolerability is generally favourable, but local reactions, transient salivation after licking and rare reversible systemic or neurologic signs can occur. Rabbits must not be treated; age, weight, illness and reproductive-use restrictions apply.

Clinical practicality8.0/10

A single monthly Drop-Lock weight-band pipette is straightforward and adds long flea-life-cycle suppression, but the coat must be parted to skin, licking prevented and established household infestation managed environmentally.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The fixed combination is flea-centred: use against fleas alone or fleas associated with ticks. Do not choose it for a tick-only problem when the pyriproxyfen flea-life-cycle component is not clinically justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use in known hypersensitivity to either active substance or an excipient.
  • Apply directly to intact skin and prevent licking or mutual grooming until dry. Licking may cause brief salivation; rinse accidental eye or human skin exposure promptly.
  • The product is not a repellent. Ticks may attach before dying and infection transmission cannot be completely excluded; cats have only one week of labelled persistent tick efficacy.
  • Do not use below the exact label minimum: cats under 10 weeks or 1 kg, and dogs under 10 weeks or 2 kg. Use only the correct species and weight-band pipette.
  • Safety during pregnancy and lactation is not established; use only after the veterinarian’s benefit-risk assessment. Keep treated animals and discarded pipettes away from watercourses.
Assessment sources
  1. VMD Effipro Duo cat leaflet2025
  2. Effipro Duo feline tick study2016
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil50 mg Pyriproxyfen60 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Manufacturer (register)
VIRBAC, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1047, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 50მგ/60მგ დასაწვეთებელი ხსნარი კატებისათვის
№ 76-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
For a cat weighing 1-6 kg apply one pipette of 0.5 ml per cat corresponding to the minimum recommended dose of 8.3 mg fipronil/kg b.w. and 10 mg pyriproxyfen/kg b.w. do not repeat the treatment at intervals of less than 4 weeks.
 Cat 1–6 kg On the skin not more often than every 4 weeks Product label (SPC)
2 pipettes
>6-12 kg 1 ml 100 [mg fipronil] 120 [mg pyriproxyfen] For a cat weighing more than 6 kg a recommended dose of 1 ml should be applied, which can be achieved by applying two 0.5 ml pipettes.
 Cat 6–12 kg On the skin not more often than every 4 weeks Product label (SPC)
No dose for this species
This pipette is for cats. For dogs, use Effipro Duo 67/20, 134/40, 268/80, or 402/120.
 Dog Any weight On the skin - Product label (SPC)
67 mg/20 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 67მგ/20მგ დასაწვეთებელი ხსნარი პატარა ძაღლებისთვის (2-10კგ)
№ 84-11
Verified on: 15 Oct 2026
67 mg/20 mg, Spot-on · Dog 2–10 kg Dog 2–10 kg 1 pipette
Apply one pipette of 0.67 ml per dog for a dog weighing from 2 to 10 kg corresponding to the minimal recommended dose of 6.7 mg fipronil /kg b.w. and 2 mg pyriproxyfen/kg b.w. In absence of safety data, the veterinary medicinal product should not be used in puppies less than 10 weeks old and/or weighing less than 2 kg. do not repeat the treatment at intervals of less than 4 weeks.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 67მგ/20მგ დასაწვეთებელი ხსნარი პატარა ძაღლებისთვის (2-10კგ)
№ 84-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effipro Duo 67 mg/20 mg, Spot-on

fipronil 67 mg + pyriproxyfen 20.1 mg, spot-on solution for dogs 2-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Effipro Duo

67 mg/20 mg, fipronil 67 mg + pyriproxyfen 20.1 mg, spot-on solution for dogs 2-10 kg
Assessed clinical scopeDog · Full canine flea-centred label: flea treatment/prevention, 12-week inhibition of flea development, FAD strategy, and tick treatment when fleas are present or also require control · On the skin
Care settingOne exact species/weight-band pipette on intact dry skin after weighing and parasite assessment, with environmental flea control when needed
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 84-11 · Verified on 15 Oct 2026

A well-regulated flea-centred fixed combination with useful 12-week immature-stage control and labelled tick activity. It is a strong exact-form option when both components fit the clinical goal, but it is not a repellent and tick protection is not uniform across species.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia and the product line retains current UK regulatory records, exact official product information and a favourable fixed-combination assessment.

Clinical efficacy7.5/10

Regulatory studies and product-specific controlled or field data support adult-flea control, 12-week inhibition of flea development and labelled tick activity. Tick persistence is species-dependent and shorter in cats, while correct skin application and environmental pressure materially affect outcome.

Safety and tolerability8.0/10

Label-dose tolerability is generally favourable, but local reactions, transient salivation after licking and rare reversible systemic or neurologic signs can occur. Rabbits must not be treated; age, weight, illness and reproductive-use restrictions apply.

Clinical practicality8.0/10

A single monthly Drop-Lock weight-band pipette is straightforward and adds long flea-life-cycle suppression, but the coat must be parted to skin, licking prevented and established household infestation managed environmentally.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The fixed combination is flea-centred: use against fleas alone or fleas associated with ticks. Do not choose it for a tick-only problem when the pyriproxyfen flea-life-cycle component is not clinically justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use in known hypersensitivity to either active substance or an excipient.
  • Apply directly to intact skin and prevent licking or mutual grooming until dry. Licking may cause brief salivation; rinse accidental eye or human skin exposure promptly.
  • The product is not a repellent. Ticks may attach before dying and infection transmission cannot be completely excluded; cats have only one week of labelled persistent tick efficacy.
  • Do not use below the exact label minimum: cats under 10 weeks or 1 kg, and dogs under 10 weeks or 2 kg. Use only the correct species and weight-band pipette.
  • Safety during pregnancy and lactation is not established; use only after the veterinarian’s benefit-risk assessment. Keep treated animals and discarded pipettes away from watercourses.
Assessment sources
  1. VMD Effipro Duo dog assessment2019
  2. VMD Effipro Duo dog M PAA2025
  3. Effipro Duo canine tick field study2016
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil67 mg Pyriproxyfen20.1 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 67მგ/20მგ დასაწვეთებელი ხსნარი პატარა ძაღლებისთვის (2-10კგ)
№ 84-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Apply one pipette of 0.67 ml per dog for a dog weighing from 2 to 10 kg corresponding to the minimal recommended dose of 6.7 mg fipronil /kg b.w. and 2 mg pyriproxyfen/kg b.w. In absence of safety data, the veterinary medicinal product should not be used in puppies less than 10 weeks old and/or weighing less than 2 kg. do not repeat the treatment at intervals of less than 4 weeks.
 Dog 2–10 kg On the skin not more often than every 4 weeks Product label (SPC)
134 mg/40 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 134მგ/40მგ დასაწვეთებელი ხსნარი საშუალო ზომის ძაღლებისთვის(10-20კგ)
№ 81-11
Verified on: 15 Oct 2026
134 mg/40 mg, Spot-on · Dog 10–20 kg Dog 10–20 kg 1 pipette
Apply one pipette of 1.34 ml per dog for a dog weighing from 10 to 20 kg
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 134მგ/40მგ დასაწვეთებელი ხსნარი საშუალო ზომის ძაღლებისთვის(10-20კგ)
№ 81-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effipro Duo 134 mg/40 mg, Spot-on

fipronil 134 mg + pyriproxyfen 40.2 mg, spot-on solution for dogs 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Effipro Duo

134 mg/40 mg, fipronil 134 mg + pyriproxyfen 40.2 mg, spot-on solution for dogs 10-20 kg
Assessed clinical scopeDog · Full canine flea-centred label: flea treatment/prevention, 12-week inhibition of flea development, FAD strategy, and tick treatment when fleas are present or also require control · On the skin
Care settingOne exact species/weight-band pipette on intact dry skin after weighing and parasite assessment, with environmental flea control when needed
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 81-11 · Verified on 15 Oct 2026

A well-regulated flea-centred fixed combination with useful 12-week immature-stage control and labelled tick activity. It is a strong exact-form option when both components fit the clinical goal, but it is not a repellent and tick protection is not uniform across species.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia and the product line retains current UK regulatory records, exact official product information and a favourable fixed-combination assessment.

Clinical efficacy7.5/10

Regulatory studies and product-specific controlled or field data support adult-flea control, 12-week inhibition of flea development and labelled tick activity. Tick persistence is species-dependent and shorter in cats, while correct skin application and environmental pressure materially affect outcome.

Safety and tolerability8.0/10

Label-dose tolerability is generally favourable, but local reactions, transient salivation after licking and rare reversible systemic or neurologic signs can occur. Rabbits must not be treated; age, weight, illness and reproductive-use restrictions apply.

Clinical practicality8.0/10

A single monthly Drop-Lock weight-band pipette is straightforward and adds long flea-life-cycle suppression, but the coat must be parted to skin, licking prevented and established household infestation managed environmentally.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The fixed combination is flea-centred: use against fleas alone or fleas associated with ticks. Do not choose it for a tick-only problem when the pyriproxyfen flea-life-cycle component is not clinically justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use in known hypersensitivity to either active substance or an excipient.
  • Apply directly to intact skin and prevent licking or mutual grooming until dry. Licking may cause brief salivation; rinse accidental eye or human skin exposure promptly.
  • The product is not a repellent. Ticks may attach before dying and infection transmission cannot be completely excluded; cats have only one week of labelled persistent tick efficacy.
  • Do not use below the exact label minimum: cats under 10 weeks or 1 kg, and dogs under 10 weeks or 2 kg. Use only the correct species and weight-band pipette.
  • Safety during pregnancy and lactation is not established; use only after the veterinarian’s benefit-risk assessment. Keep treated animals and discarded pipettes away from watercourses.
Assessment sources
  1. VMD Effipro Duo dog assessment2019
  2. VMD Effipro Duo dog M PAA2025
  3. Effipro Duo canine tick field study2016
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil134 mg Pyriproxyfen40.2 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Manufacturer (register)
VIRBAC, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1050, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 134მგ/40მგ დასაწვეთებელი ხსნარი საშუალო ზომის ძაღლებისთვის(10-20კგ)
№ 81-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Apply one pipette of 1.34 ml per dog for a dog weighing from 10 to 20 kg
 Dog 10–20 kg On the skin not more often than every 4 weeks Product label (SPC)
268 mg/80 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 268მგ/80მგ დასაწვეთებელი ხსნარი დიდი ზომის ძაღლებისთვის (20-40კგ)
№ 89-11
Verified on: 15 Oct 2026
268 mg/80 mg, Spot-on · Dog 20–40 kg Dog 20–40 kg 1 pipette
Apply one pipette of 2.68 ml per dog for a dog weighing from 20 to 40 kg
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 268მგ/80მგ დასაწვეთებელი ხსნარი დიდი ზომის ძაღლებისთვის (20-40კგ)
№ 89-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effipro Duo 268 mg/80 mg, Spot-on

fipronil 268 mg + pyriproxyfen 80.4 mg, spot-on solution for dogs 20-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Effipro Duo

268 mg/80 mg, fipronil 268 mg + pyriproxyfen 80.4 mg, spot-on solution for dogs 20-40 kg
Assessed clinical scopeDog · Full canine flea-centred label: flea treatment/prevention, 12-week inhibition of flea development, FAD strategy, and tick treatment when fleas are present or also require control · On the skin
Care settingOne exact species/weight-band pipette on intact dry skin after weighing and parasite assessment, with environmental flea control when needed
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 89-11 · Verified on 15 Oct 2026

A well-regulated flea-centred fixed combination with useful 12-week immature-stage control and labelled tick activity. It is a strong exact-form option when both components fit the clinical goal, but it is not a repellent and tick protection is not uniform across species.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia and the product line retains current UK regulatory records, exact official product information and a favourable fixed-combination assessment.

Clinical efficacy7.5/10

Regulatory studies and product-specific controlled or field data support adult-flea control, 12-week inhibition of flea development and labelled tick activity. Tick persistence is species-dependent and shorter in cats, while correct skin application and environmental pressure materially affect outcome.

Safety and tolerability8.0/10

Label-dose tolerability is generally favourable, but local reactions, transient salivation after licking and rare reversible systemic or neurologic signs can occur. Rabbits must not be treated; age, weight, illness and reproductive-use restrictions apply.

Clinical practicality8.0/10

A single monthly Drop-Lock weight-band pipette is straightforward and adds long flea-life-cycle suppression, but the coat must be parted to skin, licking prevented and established household infestation managed environmentally.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The fixed combination is flea-centred: use against fleas alone or fleas associated with ticks. Do not choose it for a tick-only problem when the pyriproxyfen flea-life-cycle component is not clinically justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use in known hypersensitivity to either active substance or an excipient.
  • Apply directly to intact skin and prevent licking or mutual grooming until dry. Licking may cause brief salivation; rinse accidental eye or human skin exposure promptly.
  • The product is not a repellent. Ticks may attach before dying and infection transmission cannot be completely excluded; cats have only one week of labelled persistent tick efficacy.
  • Do not use below the exact label minimum: cats under 10 weeks or 1 kg, and dogs under 10 weeks or 2 kg. Use only the correct species and weight-band pipette.
  • Safety during pregnancy and lactation is not established; use only after the veterinarian’s benefit-risk assessment. Keep treated animals and discarded pipettes away from watercourses.
Assessment sources
  1. VMD Effipro Duo dog assessment2019
  2. VMD Effipro Duo dog M PAA2025
  3. Effipro Duo canine tick field study2016
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil268 mg Pyriproxyfen80.4 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Manufacturer (register)
VIRBAC, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1058, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 268მგ/80მგ დასაწვეთებელი ხსნარი დიდი ზომის ძაღლებისთვის (20-40კგ)
№ 89-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Apply one pipette of 2.68 ml per dog for a dog weighing from 20 to 40 kg
 Dog 20–40 kg On the skin not more often than every 4 weeks Product label (SPC)
402 mg/120 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 402მგ/120მგ დასაწვეთებელი ხსნარი ძალიან დიდი ზომის ძაღლებისათვის (40-60კგ)
№ 105-11
Verified on: 15 Oct 2026
402 mg/120 mg, Spot-on · Dog 40–60 kg Dog 40–60 kg 1 pipette
Apply one pipette of 4.02 ml per dog for a dog weighing from 40 to 60 kg For dogs over 60 kg the appropriate combination of pipettes should be used.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 402მგ/120მგ დასაწვეთებელი ხსნარი ძალიან დიდი ზომის ძაღლებისათვის (40-60კგ)
№ 105-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effipro Duo 402 mg/120 mg, Spot-on

fipronil 402 mg + pyriproxyfen 120.6 mg, spot-on solution for dogs 40-60 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Effipro Duo

402 mg/120 mg, fipronil 402 mg + pyriproxyfen 120.6 mg, spot-on solution for dogs 40-60 kg
Assessed clinical scopeDog · Full canine flea-centred label: flea treatment/prevention, 12-week inhibition of flea development, FAD strategy, and tick treatment when fleas are present or also require control · On the skin
Care settingOne exact species/weight-band pipette on intact dry skin after weighing and parasite assessment, with environmental flea control when needed
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 105-11 · Verified on 15 Oct 2026

A well-regulated flea-centred fixed combination with useful 12-week immature-stage control and labelled tick activity. It is a strong exact-form option when both components fit the clinical goal, but it is not a repellent and tick protection is not uniform across species.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia and the product line retains current UK regulatory records, exact official product information and a favourable fixed-combination assessment.

Clinical efficacy7.5/10

Regulatory studies and product-specific controlled or field data support adult-flea control, 12-week inhibition of flea development and labelled tick activity. Tick persistence is species-dependent and shorter in cats, while correct skin application and environmental pressure materially affect outcome.

Safety and tolerability8.0/10

Label-dose tolerability is generally favourable, but local reactions, transient salivation after licking and rare reversible systemic or neurologic signs can occur. Rabbits must not be treated; age, weight, illness and reproductive-use restrictions apply.

Clinical practicality8.0/10

A single monthly Drop-Lock weight-band pipette is straightforward and adds long flea-life-cycle suppression, but the coat must be parted to skin, licking prevented and established household infestation managed environmentally.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The fixed combination is flea-centred: use against fleas alone or fleas associated with ticks. Do not choose it for a tick-only problem when the pyriproxyfen flea-life-cycle component is not clinically justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use in known hypersensitivity to either active substance or an excipient.
  • Apply directly to intact skin and prevent licking or mutual grooming until dry. Licking may cause brief salivation; rinse accidental eye or human skin exposure promptly.
  • The product is not a repellent. Ticks may attach before dying and infection transmission cannot be completely excluded; cats have only one week of labelled persistent tick efficacy.
  • Do not use below the exact label minimum: cats under 10 weeks or 1 kg, and dogs under 10 weeks or 2 kg. Use only the correct species and weight-band pipette.
  • Safety during pregnancy and lactation is not established; use only after the veterinarian’s benefit-risk assessment. Keep treated animals and discarded pipettes away from watercourses.
Assessment sources
  1. VMD Effipro Duo dog assessment2019
  2. VMD Effipro Duo dog M PAA2025
  3. Effipro Duo canine tick field study2016
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil402 mg Pyriproxyfen120.6 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Manufacturer (register)
VIRBAC, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1071, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფფიპრო® დუო 402მგ/120მგ დასაწვეთებელი ხსნარი ძალიან დიდი ზომის ძაღლებისათვის (40-60კგ)
№ 105-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
This pipette is for dogs. Use the feline Effipro Duo 50 mg/60 mg product for cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Apply one pipette of 4.02 ml per dog for a dog weighing from 40 to 60 kg For dogs over 60 kg the appropriate combination of pipettes should be used.
 Dog 40–60 kg On the skin not more often than every 4 weeks Product label (SPC)
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Pyriproxyfen
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
2 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 67 mg/20 mg Spot-on Solution for Small Dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
10 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD
  • Critical Pyriproxyfen
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Caution Pyriproxyfen
    Laboratory studies in dogs have not produced any evidence of teratogenic or embryotoxic effects. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Caution Pyriproxyfen
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD

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