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Fipronil · Barrier-Profi / Product LLC

3 forms: spot-on, topical (unspecified). In force in Georgia: 3 of 3 (veterinary register).

Forms and doses3 of 3 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Topical (unspecified) · Cat Any weight Cat Any weight 1 collar
Open immediately before use. Fit leaving 1-1.5 cm between neck and collar, allow free movement and trim excess while allowing for growth. Wetting may reduce efficacy. Do not use below 10 weeks of age, in sick, convalescent, debilitated or old animals, or during pregnancy/lactation. Remove for local alopecia, pruritus or irritation. Chewing/ingestion may cause ataxia, hyperreactivity, tremor, seizures, vomiting, dizziness or weakness; remove exposure and seek urgent veterinary care. Wash hands after handling.
 · fit one collar continuously; protection up to 6 months		 fit one collar continuously; protection up to 6 months Georgia Yes, veterinary
In force until 17 Jul 2028
Veterinary (National Food Agency)
In the register: ბარიერ სუპერი ინსექტოაკარიციდული საყელო კატებისთვის
№ 000391
Verified on: 22 Oct 2026
Details: pack, label wording, sources, registration

Barrier Super, Topical (unspecified)

fipronil 40 mg/g collar, 32.5 +/- 2.5 cm for cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
5.0/10
Weak evidence support
vetman assessment

Barrier Super

fipronil 40 mg/g collar, 32.5 +/- 2.5 cm for cats
Assessed clinical scopeCat · Full cat label from 10 weeks: prevention and control of flea and tick infestation with a fipronil 40 mg/g collar worn for up to 6 months · On the skin
Care settingOwner-applied preventive collar for a healthy adult cat, with attention to collar fit and entrapment risk
vetman score 5.0/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000391 · Verified on 22 Oct 2026

A weak option for cats: fipronil itself is cat-safe, but the collar claim is unproven and entrapment and chewing risks remain. A cat-authorised spot-on is better supported.

Regulatory and scientific credibility4.0/10

The exact collar is registered in Georgia (000391, valid to 2028) with a current Ukrainian manufacturer instruction, but no EU, UK or US authorisation was documented in the reviewed evidence and no public efficacy dossier.

Clinical efficacy4.0/10

Fipronil works well in cats as a spot-on or spray, but no independent study supports 6-month flea and tick control from a fipronil collar.

Safety and tolerability6.0/10

Fipronil is safe in cats at label doses, but the label warns of neurological signs after chewing or ingestion, and no breakaway release is described for this cat collar.

Clinical practicality6.5/10

A single collar is easy to fit, but cats may lose or chew it and wetting reduces efficacy.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in kittens under 10 weeks, sick, convalescent, debilitated or old cats, or during pregnancy and lactation.
  • If the collar is chewed or swallowed by the cat, another pet or a child, remove it and seek urgent care: ataxia, tremor, seizures and vomiting are possible.
  • No breakaway release is described: check the fit regularly so a jaw or leg cannot get caught.
  • Remove the collar if local hair loss, itching or skin irritation develops.
  • Wetting may reduce efficacy; wash hands after handling.
Assessment sources
  1. Barrier Super cat collar2026
  2. Georgia NFA register 20262026
  3. ESCCAP ectoparasite guideline2024
  4. CAPC flea guideline2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil40 mg/g
Formulation Type
Topical (unspecified)
Administration route
On the skin
Manufacturer (register)
Private Enterprise Barrier-Profi, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 870, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 17 Jul 2028
Veterinary (National Food Agency)
In the register: ბარიერ სუპერი ინსექტოაკარიციდული საყელო კატებისთვის
№ 000391
Verified on: 22 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 collar
Open immediately before use. Fit leaving 1-1.5 cm between neck and collar, allow free movement and trim excess while allowing for growth. Wetting may reduce efficacy. Do not use below 10 weeks of age, in sick, convalescent, debilitated or old animals, or during pregnancy/lactation. Remove for local alopecia, pruritus or irritation. Chewing/ingestion may cause ataxia, hyperreactivity, tremor, seizures, vomiting, dizziness or weakness; remove exposure and seek urgent veterinary care. Wash hands after handling.
 Cat Any weight On the skin fit one collar continuously; protection up to 6 months
Barrier Super cat collar
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 40 mg/g collar for cats - current manufacturer instruction
Current manufacturer product instruction, 2026
Topical (unspecified) · Dog Any weight Dog Any weight 1 collar
Open immediately before use. Fit leaving 1-1.5 cm between neck and collar, allow free movement and trim excess while allowing for growth. Wetting may reduce efficacy. Do not use below 10 weeks of age, in sick, convalescent, debilitated or old animals, or during pregnancy/lactation. Remove for local alopecia, pruritus or irritation. Chewing/ingestion may cause ataxia, hyperreactivity, tremor, seizures, vomiting, dizziness or weakness; remove exposure and seek urgent veterinary care. Wash hands after handling.
 · fit one collar continuously; protection up to 6 months		 fit one collar continuously; protection up to 6 months Georgia Yes, veterinary
In force until 17 Jul 2028
Veterinary (National Food Agency)
In the register: ბარიერ სუპერი ინსექტოაკარიციდული საყელო ძაღლებისთვის
№ 000404
Verified on: 22 Oct 2026
Details: pack, label wording, sources, registration

Barrier Super, Topical (unspecified)

fipronil 40 mg/g collar, 65 +/- 5 cm for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.1/10
Weak evidence support
vetman assessment

Barrier Super

fipronil 40 mg/g collar, 65 +/- 5 cm for dogs
Assessed clinical scopeDog · Full dog label from 10 weeks: prevention and control of flea and tick infestation with a fipronil 40 mg/g collar worn for up to 6 months · On the skin
Care settingOwner-applied preventive collar for a healthy adult dog, after veterinary advice on tick-borne disease risk
vetman score 5.1/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000404 · Verified on 22 Oct 2026

A weak option: an easy collar, but the 6-month fipronil collar claim has no independent support. EU-authorised collars or fipronil spot-ons are better documented.

Regulatory and scientific credibility4.0/10

The exact collar is registered in Georgia (000404, valid to 2028) with a current Ukrainian manufacturer instruction, but no EU, UK or US authorisation was documented in the reviewed evidence and no public efficacy dossier.

Clinical efficacy4.0/10

Fipronil is well proven as a spot-on and spray, but no independent study shows that a fipronil collar matrix releases enough drug to kill fleas and ticks for the claimed 6 months.

Safety and tolerability6.5/10

Fipronil is well tolerated by dogs, but the label lists neurological signs after chewing or swallowing the collar and excludes puppies under 10 weeks, sick, old, pregnant and lactating dogs.

Clinical practicality6.5/10

One collar fitted with a 1-1.5 cm gap is simple, but wetting reduces efficacy and the end of protection cannot be checked.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in puppies under 10 weeks, sick, convalescent, debilitated or old dogs, or during pregnancy and lactation.
  • If the collar is chewed or swallowed by the dog, another pet or a child, remove it and seek urgent care: ataxia, tremor, seizures and vomiting are possible.
  • Remove the collar if local hair loss, itching or skin irritation develops.
  • Swimming and bathing may reduce efficacy; in tick-borne disease areas add or prefer a product with proven tick efficacy.
  • Wash hands after handling and open the pouch just before use.
Assessment sources
  1. Barrier Super dog collar2026
  2. Georgia NFA register 20262026
  3. ESCCAP ectoparasite guideline2024
  4. CAPC flea guideline2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil40 mg/g
Formulation Type
Topical (unspecified)
Administration route
On the skin
Manufacturer (register)
Private Enterprise Barrier-Profi, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 871, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 17 Jul 2028
Veterinary (National Food Agency)
In the register: ბარიერ სუპერი ინსექტოაკარიციდული საყელო ძაღლებისთვის
№ 000404
Verified on: 22 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 collar
Open immediately before use. Fit leaving 1-1.5 cm between neck and collar, allow free movement and trim excess while allowing for growth. Wetting may reduce efficacy. Do not use below 10 weeks of age, in sick, convalescent, debilitated or old animals, or during pregnancy/lactation. Remove for local alopecia, pruritus or irritation. Chewing/ingestion may cause ataxia, hyperreactivity, tremor, seizures, vomiting, dizziness or weakness; remove exposure and seek urgent veterinary care. Wash hands after handling.
 Dog Any weight On the skin fit one collar continuously; protection up to 6 months
Barrier Super dog collar
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 40 mg/g collar for dogs - current manufacturer instruction
Current manufacturer product instruction, 2026
Spot-on · Cat Any weight Cat Any weight 1 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 · apply once; repeat only if needed after 1.5-2 months		 apply once; repeat only if needed after 1.5-2 months Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Spot-on · Cat Any weight Cat Any weight 2–3 drops
For label treatment of otodectosis only: instil 2-3 drops into the external ear canal. Confirm tympanic membrane integrity and veterinary diagnosis before otic use. Follow all age, physiological-state and adverse-reaction restrictions in the topical label.
 · repeat 2-3 times at intervals of 8-10 days		 repeat 2-3 times at intervals of 8-10 days Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Spot-on · Dog Any weight Dog Any weight 2–3 drops
For label treatment of otodectosis only: instil 2-3 drops into the external ear canal. Confirm tympanic membrane integrity and veterinary diagnosis before otic use. Follow all age, physiological-state and adverse-reaction restrictions in the topical label.
 · repeat 2-3 times at intervals of 8-10 days		 repeat 2-3 times at intervals of 8-10 days Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Spot-on · Dog 2–10 kg Dog 2–10 kg 1 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 · apply once; repeat only if needed after 1.5-2 months		 apply once; repeat only if needed after 1.5-2 months Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Spot-on · Dog 10–20 kg Dog 10–20 kg 2 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 · apply once; repeat only if needed after 1.5-2 months		 apply once; repeat only if needed after 1.5-2 months Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Spot-on · Dog 20–40 kg Dog 20–40 kg 3 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 · apply once; repeat only if needed after 1.5-2 months		 apply once; repeat only if needed after 1.5-2 months Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Spot-on · Dog over 40 kg Dog over 40 kg 4 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 · apply once; repeat only if needed after 1.5-2 months		 apply once; repeat only if needed after 1.5-2 months Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Details: pack, label wording, sources, registration

Barrier Super, Spot-on

fipronil 80 mg/ml drops, 3 x 1 ml for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal
4.4/10
Weak evidence support
vetman assessment

Barrier Super

fipronil 80 mg/ml drops, 3 x 1 ml for dogs and cats
Assessed clinical scopeDog · Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal · auricular
Care settingVeterinary diagnosis after otoscopy and microscopy; clean the external canal, verify tympanic membrane integrity and reassess before repetition.
vetman score 4.4/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000369 · Verified on 22 Oct 2026

A weak, low-confidence label-supported otic option: the regimen is stated, but exact-formulation efficacy and ototoxicity evidence are absent. Prefer a product with regulator-reviewed otic data and always confirm an intact tympanum.

Regulatory and scientific credibility5.0/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The current manufacturer instruction identifies the exact 3 x 1 ml presentation, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found.

Clinical efficacy3.5/10

The exact instruction provides an otic regimen, but no exact-product controlled auricular efficacy study was found. Evidence for fipronil spot-on control of fleas and ticks is not direct evidence for this solvent, concentration and repeated ear-canal regimen.

Safety and tolerability3.5/10

Exact-formulation ear-canal safety and ototoxicity data were not found. Use only after confirming an intact tympanic membrane; stop for pain, neurologic signs, marked irritation or hearing change. Class safety from dermal spot-on use cannot be assumed to prove otic safety.

Clinical practicality6.5/10

Two to three drops per ear repeated two or three times at 8-10 day intervals is measurable, but requires cleaning, bilateral dosing, massage, restraint and reassessment. The dropper presentation is workable but not a one-step spot-on regimen.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Confirm otodectosis by otoscopy/microscopy and verify an intact tympanic membrane before use. Do not apply into a perforated, unvisualised, severely inflamed or neurologically abnormal ear.
  • Clean both external canals, treat both ears even with unilateral signs and massage the ear base as directed. Stop and reassess for pain, head tilt, nystagmus, ataxia, hearing change or marked irritation.
  • Spot-on flea/tick efficacy and dermal safety studies do not establish efficacy or ototoxicity safety for this exact repeated ear-canal regimen. Evidence confidence is low.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
  1. Barrier Super drops2026
  2. VMD Frontline dog SPC2026
  3. ESCCAP GL32026
  4. Fipronil dog spot-on RCTs2013
  5. Fipronil dog formulation RCT2010
  6. Fipronil household flea field study2000
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Dog Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them
5.3/10
Weak evidence support
vetman assessment

Barrier Super

fipronil 80 mg/ml drops, 3 x 1 ml for dogs and cats
Assessed clinical scopeDog · Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them · On the skin
Care settingHome topical administration after veterinary selection of parasite target, weight band and retreatment interval; environmental control and household coverage as clinically indicated.
vetman score 5.3/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000369 · Verified on 22 Oct 2026

A weak exact-presentation option: fipronil class efficacy is credible, but dose design, broad claims or formulation-specific evidence are less convincing than current regulator-reviewed comparators. Use only within the exact label and reassess control rather than assuming class equivalence.

Regulatory and scientific credibility5.0/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The current manufacturer instruction identifies the exact 3 x 1 ml presentation, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found.

Clinical efficacy4.5/10

Fipronil spot-on has controlled dog/cat evidence for fleas and ticks, but the exact 80 mg/ml product has no independent outcome study. The claimed 1.5-2 month protection and broad mite scope exceed or differ from current authorised comparator durations and therefore remain manufacturer-supported claims.

Safety and tolerability5.0/10

The instruction excludes young, sick, debilitated, old, pregnant or lactating animals and describes local alopecia, pruritus, irritation and systemic overdose signs. Exact-formulation frequency and margin are not independently characterised, and the fixed 1 ml feline dose exceeds the 0.5 ml authorised comparator volume.

Clinical practicality7.5/10

One-millilitre ampoules are simple for an adult cat or 2-10 kg dog, but larger dogs require two to four ampoules. The claimed 1.5-2 month interval is convenient but should not substitute for parasite- and exposure-based reassessment.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only on dry, intact skin in an area the animal cannot lick. Weigh the patient, select the exact label band and do not extrapolate between products, concentrations or pipette sizes.
  • Fipronil does not reliably prevent tick attachment or pathogen transmission. Examine the patient after exposure and use an integrated parasite plan based on local epidemiology and lifestyle.
  • The exact product has no independent controlled outcome trial or public regulator assessment dossier. Class evidence supports fipronil, not every broader mite, repellent or persistence claim on this formulation.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
  1. Barrier Super drops2026
  2. VMD Frontline dog SPC2026
  3. ESCCAP GL32026
  4. Fipronil dog spot-on RCTs2013
  5. Fipronil dog formulation RCT2010
  6. Fipronil household flea field study2000
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal
4.4/10
Weak evidence support
vetman assessment

Barrier Super

fipronil 80 mg/ml drops, 3 x 1 ml for dogs and cats
Assessed clinical scopeCat · Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal · auricular
Care settingVeterinary diagnosis after otoscopy and microscopy; clean the external canal, verify tympanic membrane integrity and reassess before repetition.
vetman score 4.4/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000369 · Verified on 22 Oct 2026

A weak, low-confidence label-supported otic option: the regimen is stated, but exact-formulation efficacy and ototoxicity evidence are absent. Prefer a product with regulator-reviewed otic data and always confirm an intact tympanum.

Regulatory and scientific credibility5.0/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The current manufacturer instruction identifies the exact 3 x 1 ml presentation, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found.

Clinical efficacy3.5/10

The exact instruction provides an otic regimen, but no exact-product controlled auricular efficacy study was found. Evidence for fipronil spot-on control of fleas and ticks is not direct evidence for this solvent, concentration and repeated ear-canal regimen.

Safety and tolerability3.5/10

Exact-formulation ear-canal safety and ototoxicity data were not found. Use only after confirming an intact tympanic membrane; stop for pain, neurologic signs, marked irritation or hearing change. Class safety from dermal spot-on use cannot be assumed to prove otic safety.

Clinical practicality6.5/10

Two to three drops per ear repeated two or three times at 8-10 day intervals is measurable, but requires cleaning, bilateral dosing, massage, restraint and reassessment. The dropper presentation is workable but not a one-step spot-on regimen.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Confirm otodectosis by otoscopy/microscopy and verify an intact tympanic membrane before use. Do not apply into a perforated, unvisualised, severely inflamed or neurologically abnormal ear.
  • Clean both external canals, treat both ears even with unilateral signs and massage the ear base as directed. Stop and reassess for pain, head tilt, nystagmus, ataxia, hearing change or marked irritation.
  • Spot-on flea/tick efficacy and dermal safety studies do not establish efficacy or ototoxicity safety for this exact repeated ear-canal regimen. Evidence confidence is low.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
  1. Barrier Super drops2026
  2. VMD Frontline cat SPC2026
  3. ESCCAP GL32026
  4. Fipronil cat spot-on RCTs2012
  5. VMD FleaCidal cat assessment2016
  6. Fipronil household flea field study2000
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them
5.1/10
Weak evidence support
vetman assessment

Barrier Super

fipronil 80 mg/ml drops, 3 x 1 ml for dogs and cats
Assessed clinical scopeCat · Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them · On the skin
Care settingHome topical administration after veterinary selection of parasite target, weight band and retreatment interval; environmental control and household coverage as clinically indicated.
vetman score 5.1/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000369 · Verified on 22 Oct 2026

A weak exact-presentation option: fipronil class efficacy is credible, but dose design, broad claims or formulation-specific evidence are less convincing than current regulator-reviewed comparators. Use only within the exact label and reassess control rather than assuming class equivalence.

Regulatory and scientific credibility5.0/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The current manufacturer instruction identifies the exact 3 x 1 ml presentation, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found.

Clinical efficacy4.5/10

Fipronil spot-on has controlled dog/cat evidence for fleas and ticks, but the exact 80 mg/ml product has no independent outcome study. The claimed 1.5-2 month protection and broad mite scope exceed or differ from current authorised comparator durations and therefore remain manufacturer-supported claims.

Safety and tolerability4.5/10

The instruction excludes young, sick, debilitated, old, pregnant or lactating animals and describes local alopecia, pruritus, irritation and systemic overdose signs. Exact-formulation frequency and margin are not independently characterised, and the fixed 1 ml feline dose exceeds the 0.5 ml authorised comparator volume.

Clinical practicality7.5/10

One-millilitre ampoules are simple for an adult cat or 2-10 kg dog, but larger dogs require two to four ampoules. The claimed 1.5-2 month interval is convenient but should not substitute for parasite- and exposure-based reassessment.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only on dry, intact skin in an area the animal cannot lick. Weigh the patient, select the exact label band and do not extrapolate between products, concentrations or pipette sizes.
  • Fipronil does not reliably prevent tick attachment or pathogen transmission. Examine the patient after exposure and use an integrated parasite plan based on local epidemiology and lifestyle.
  • The exact product has no independent controlled outcome trial or public regulator assessment dossier. Class evidence supports fipronil, not every broader mite, repellent or persistence claim on this formulation.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
  1. Barrier Super drops2026
  2. VMD Frontline cat SPC2026
  3. ESCCAP GL32026
  4. Fipronil cat spot-on RCTs2012
  5. VMD FleaCidal cat assessment2016
  6. Fipronil household flea field study2000
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil80 mg/ml
Formulation Type
Spot-on
Administration route
On the skin, auricular
Manufacturer (register)
Private Enterprise Barrier-Profi, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 860, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 21 Jun 2028
Veterinary (National Food Agency)
In the register: ინსექტოაკარიციდული წვეთები ბარიერი სუპერი
№ 000369
Verified on: 22 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 Cat Any weight On the skin apply once; repeat only if needed after 1.5-2 months
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
2–3 drops
For label treatment of otodectosis only: instil 2-3 drops into the external ear canal. Confirm tympanic membrane integrity and veterinary diagnosis before otic use. Follow all age, physiological-state and adverse-reaction restrictions in the topical label.
 Cat Any weight auricular repeat 2-3 times at intervals of 8-10 days
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
2–3 drops
For label treatment of otodectosis only: instil 2-3 drops into the external ear canal. Confirm tympanic membrane integrity and veterinary diagnosis before otic use. Follow all age, physiological-state and adverse-reaction restrictions in the topical label.
 Dog Any weight auricular repeat 2-3 times at intervals of 8-10 days
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
1 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 Dog 2–10 kg On the skin apply once; repeat only if needed after 1.5-2 months
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
2 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 Dog 10–20 kg On the skin apply once; repeat only if needed after 1.5-2 months
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
3 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 Dog 20–40 kg On the skin apply once; repeat only if needed after 1.5-2 months
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
4 ml (1 ml)
Apply directly to dry, intact skin where licking is prevented. Adult cats: 1 ml. Dogs: use the weight-band amount. The exact instruction separately states 0.5 ml for puppies and kittens, but age is not a calculator input: do not use in puppies under 10 weeks or kittens under 12 weeks and verify the juvenile label before dosing. Do not use in sick, debilitated or old animals, or during pregnancy/lactation. Local alopecia, pruritus or irritation may occur; wash off with soap and water and seek veterinary advice if a reaction or overdose signs (depression, salivation, tremor, vomiting) occur. Do not apply to wet/damaged skin, bathe for 48 hours, or allow petting/contact with young children for 24 hours.
 Dog over 40 kg On the skin apply once; repeat only if needed after 1.5-2 months
Barrier Super drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Barrier Super fipronil 80 mg/ml drops - current manufacturer instruction
Current manufacturer product instruction, 2026
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD

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Same therapeutic group 79

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