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Perfect Trio

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Fipronil + Ivermectin + Pyriproxyfen · Vetsintez LLC

4 forms: spot-on. In force in Georgia: 4 of 4 (veterinary register).

Forms and doses4 of 4 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
100/15/20 mg/ml spot-on, Spot-on · Cat 2–4 kg Cat 2–4 kg 0.6 ml (0.6 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 · apply one complete pipette once; repeat only as directed		 apply one complete pipette once; repeat only as directed Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000802
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Perfect Trio 100/15/20 mg/ml spot-on, Spot-on

0.6 ml N3 for cats 2-4 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
5.8/10
Weak evidence support
vetman assessment

Perfect Trio

100/15/20 mg/ml spot-on, 0.6 ml N3 for cats 2-4 kg
Assessed clinical scopeCat · Full labelled feline topical scope in the exact weight band: fleas, lice, biting lice, ticks and mites; gastrointestinal nematodes; Dirofilaria larval prevention · On the skin
Care settingVeterinary-selected home spot-on use after parasite identification and heartworm-risk assessment, with follow-up for established infestation or infection
vetman score 5.8/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000802 · Verified on 21 Oct 2026

Locally registered exact spot-on with a positive but small exact-product field study. It may be a situational broad-spectrum option after parasite selection, but its wide claims and safety margin are less securely documented than better-studied alternatives; prevent licking and use only in cats over 3 months and 2 kg.

Regulatory and scientific credibility6.0/10

The exact presentation is actively registered in Georgia, current official manufacturer instructions verify its composition and labelled use, and an exact-product peer-reviewed field study is available. However, no EMA/FDA-style public assessment, regulator-hosted SPC or transparent full dossier for this formulation was found.

Clinical efficacy6.0/10

A 2024 exact-product field study reported high efficacy in naturally infested dogs and cats against selected fleas, lice and mites, plus feline Uncinaria, with one-month follow-up. Each parasite group contained only seven animals, the comparator and blinding are inadequately reported, and many broad label targets and prevention claims were not tested.

Safety and tolerability5.0/10

The small field study reported no adverse effects, but it cannot establish a broad safety margin or detect uncommon events. The label prohibits use in pregnancy, lactation, kittens under 3 months, cats at or below 2 kg, and sick or convalescent animals; licking, overdose and concurrent macrocyclic-lactone exposure remain important concerns.

Clinical practicality6.5/10

A whole weight-banded pipette makes routine dosing straightforward, but treatment varies by target: one application, repeated 7-10-day courses for some mites, or monthly heartworm prevention. Correct skin placement, prevention of licking, bathing restrictions, ear examination when relevant and follow-up add meaningful clinical and adherence burden.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with hypersensitivity, in animals under 3 months or at or below 2 kg, or in sick, convalescent, debilitated or emaciated patients.
  • Do not use during pregnancy or lactation; the exact combination does not have an established reproductive safety margin.
  • Do not combine with another macrocyclic lactone or antiparasitic unless a veterinarian has checked active ingredients, intervals and cumulative neurotoxicity.
  • Prevent licking and separate treated animals until dry. Monitor for local irritation, hypersalivation, vomiting, depression, ataxia, tremor or other neurologic signs; wash off and assess promptly if they occur.
  • Apply the entire exact pipette directly to dry intact skin. Do not bathe for 3 days before or after treatment and avoid handling or contact with small children for 48 hours.
  • For ear-mite treatment, examine and clean the ear first and confirm tympanic-membrane integrity; complicated otitis requires separate diagnosis and treatment.
  • Heartworm use is prevention against susceptible larval stages, not adulticide treatment. Assess exposure and infection status and follow current species-specific guidance.
  • The exact-product study is small and does not validate every broad label claim. Confirm the parasite and reassess response rather than treating label breadth as proof of coverage.
  • Fipronil is highly toxic to aquatic invertebrates and the label states toxicity to fish and bees; prevent entry into surface water and dispose of pipettes responsibly.
Assessment sources
  1. Vetsintez Perfect Trio cats
  2. Georgia NFA register 20262026
  3. Perfect Trio field study2024
  4. ESCCAP ectoparasite guideline2024
  5. ESCCAP worm control guideline2026
  6. AHS feline guidelines2024
  7. EMA ectoparasiticide environment 20232023
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil100 mg/ml Ivermectin15 mg/ml Pyriproxyfen20 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Vetsintez LLC · Ukraine
Manufacturer (register)
Vetsintez LLC, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1320, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000802
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
0.6 ml (0.6 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 Cat 2–4 kg On the skin apply one complete pipette once; repeat only as directed
Vetsintez Perfect Trio
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Perfect Trio spot-on - current official dog and cat instructions
Vetsintez official veterinary product instructions
100/15/20 mg/ml spot-on, Spot-on · Cat 4–10 kg Cat 4–10 kg 0.8 ml (0.8 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 · apply one complete pipette once; repeat only as directed		 apply one complete pipette once; repeat only as directed Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000803
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Perfect Trio 100/15/20 mg/ml spot-on, Spot-on

0.8 ml N3 for cats 4-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
5.8/10
Weak evidence support
vetman assessment

Perfect Trio

100/15/20 mg/ml spot-on, 0.8 ml N3 for cats 4-10 kg
Assessed clinical scopeCat · Full labelled feline topical scope in the exact weight band: fleas, lice, biting lice, ticks and mites; gastrointestinal nematodes; Dirofilaria larval prevention · On the skin
Care settingVeterinary-selected home spot-on use after parasite identification and heartworm-risk assessment, with follow-up for established infestation or infection
vetman score 5.8/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000803 · Verified on 21 Oct 2026

Locally registered exact spot-on with a positive but small exact-product field study. It may be a situational broad-spectrum option after parasite selection, but its wide claims and safety margin are less securely documented than better-studied alternatives; prevent licking and use only in cats over 3 months and 2 kg.

Regulatory and scientific credibility6.0/10

The exact presentation is actively registered in Georgia, current official manufacturer instructions verify its composition and labelled use, and an exact-product peer-reviewed field study is available. However, no EMA/FDA-style public assessment, regulator-hosted SPC or transparent full dossier for this formulation was found.

Clinical efficacy6.0/10

A 2024 exact-product field study reported high efficacy in naturally infested dogs and cats against selected fleas, lice and mites, plus feline Uncinaria, with one-month follow-up. Each parasite group contained only seven animals, the comparator and blinding are inadequately reported, and many broad label targets and prevention claims were not tested.

Safety and tolerability5.0/10

The small field study reported no adverse effects, but it cannot establish a broad safety margin or detect uncommon events. The label prohibits use in pregnancy, lactation, kittens under 3 months, cats at or below 2 kg, and sick or convalescent animals; licking, overdose and concurrent macrocyclic-lactone exposure remain important concerns.

Clinical practicality6.5/10

A whole weight-banded pipette makes routine dosing straightforward, but treatment varies by target: one application, repeated 7-10-day courses for some mites, or monthly heartworm prevention. Correct skin placement, prevention of licking, bathing restrictions, ear examination when relevant and follow-up add meaningful clinical and adherence burden.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with hypersensitivity, in animals under 3 months or at or below 2 kg, or in sick, convalescent, debilitated or emaciated patients.
  • Do not use during pregnancy or lactation; the exact combination does not have an established reproductive safety margin.
  • Do not combine with another macrocyclic lactone or antiparasitic unless a veterinarian has checked active ingredients, intervals and cumulative neurotoxicity.
  • Prevent licking and separate treated animals until dry. Monitor for local irritation, hypersalivation, vomiting, depression, ataxia, tremor or other neurologic signs; wash off and assess promptly if they occur.
  • Apply the entire exact pipette directly to dry intact skin. Do not bathe for 3 days before or after treatment and avoid handling or contact with small children for 48 hours.
  • For ear-mite treatment, examine and clean the ear first and confirm tympanic-membrane integrity; complicated otitis requires separate diagnosis and treatment.
  • Heartworm use is prevention against susceptible larval stages, not adulticide treatment. Assess exposure and infection status and follow current species-specific guidance.
  • The exact-product study is small and does not validate every broad label claim. Confirm the parasite and reassess response rather than treating label breadth as proof of coverage.
  • Fipronil is highly toxic to aquatic invertebrates and the label states toxicity to fish and bees; prevent entry into surface water and dispose of pipettes responsibly.
Assessment sources
  1. Vetsintez Perfect Trio cats
  2. Georgia NFA register 20262026
  3. Perfect Trio field study2024
  4. ESCCAP ectoparasite guideline2024
  5. ESCCAP worm control guideline2026
  6. AHS feline guidelines2024
  7. EMA ectoparasiticide environment 20232023
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil100 mg/ml Ivermectin15 mg/ml Pyriproxyfen20 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Vetsintez LLC · Ukraine
Manufacturer (register)
Vetsintez LLC, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1322, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000803
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
0.8 ml (0.8 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 Cat 4–10 kg On the skin apply one complete pipette once; repeat only as directed
Vetsintez Perfect Trio
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Perfect Trio spot-on - current official dog and cat instructions
Vetsintez official veterinary product instructions
100/15/20 mg/ml spot-on, Spot-on · Dog 4–10 kg Dog 4–10 kg 0.8 ml (0.8 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 · apply one complete pipette once; repeat only as directed		 apply one complete pipette once; repeat only as directed Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000804
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Perfect Trio 100/15/20 mg/ml spot-on, Spot-on

0.8 ml N3 for dogs 4-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.7/10
Weak evidence support
vetman assessment

Perfect Trio

100/15/20 mg/ml spot-on, 0.8 ml N3 for dogs 4-10 kg
Assessed clinical scopeDog · Full labelled canine topical scope in the exact weight band: fleas, lice, biting lice, mosquitoes, ticks and mites; gastrointestinal nematodes; Dirofilaria larval prevention · On the skin
Care settingVeterinary-selected home spot-on use after parasite identification and heartworm-risk assessment, with follow-up for established infestation or infection
vetman score 5.7/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000804 · Verified on 21 Oct 2026

Locally registered exact spot-on with a positive but small exact-product field study. It may be a situational broad-spectrum option after parasite selection, but its wide claims and safety margin are less securely documented than better-studied alternatives; avoid MDR1-susceptible dogs and use the exact weight band.

Regulatory and scientific credibility6.0/10

The exact presentation is actively registered in Georgia, current official manufacturer instructions verify its composition and labelled use, and an exact-product peer-reviewed field study is available. However, no EMA/FDA-style public assessment, regulator-hosted SPC or transparent full dossier for this formulation was found.

Clinical efficacy6.0/10

A 2024 exact-product field study reported high efficacy in naturally infested dogs and cats against selected fleas, lice and mites, plus feline Uncinaria, with one-month follow-up. Each parasite group contained only seven animals, the comparator and blinding are inadequately reported, and many broad label targets and prevention claims were not tested.

Safety and tolerability4.5/10

The small field study reported no adverse effects, but it cannot establish a broad safety margin or detect uncommon events. The label prohibits use in pregnancy, lactation, young, underweight, sick or convalescent animals and specifically warns against use in MDR1-mutant breeds because of possible neurotoxicity.

Clinical practicality6.5/10

A whole weight-banded pipette makes routine dosing straightforward, but treatment varies by target: one application, repeated 7-10-day courses for some mites, or monthly heartworm prevention. Correct skin placement, prevention of licking, bathing restrictions, ear examination when relevant and follow-up add meaningful clinical and adherence burden.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with hypersensitivity, in animals under 3 months or at or below 2 kg, or in sick, convalescent, debilitated or emaciated patients.
  • Do not use during pregnancy or lactation; the exact combination does not have an established reproductive safety margin.
  • Do not combine with another macrocyclic lactone or antiparasitic unless a veterinarian has checked active ingredients, intervals and cumulative neurotoxicity.
  • The label does not recommend use in Collies, Shetland Sheepdogs, Old English Sheepdogs, Scottish Shepherds or their crosses because of possible MDR1-associated neurotoxicity.
  • Prevent licking and separate treated animals until dry. Monitor for local irritation, hypersalivation, vomiting, depression, ataxia, tremor or other neurologic signs; wash off and assess promptly if they occur.
  • Apply the entire exact pipette directly to dry intact skin. Do not bathe for 3 days before or after treatment and avoid handling or contact with small children for 48 hours.
  • For ear-mite treatment, examine and clean the ear first and confirm tympanic-membrane integrity; complicated otitis requires separate diagnosis and treatment.
  • Heartworm use is prevention against susceptible larval stages, not adulticide treatment. Assess exposure and infection status and follow current species-specific guidance.
  • The exact-product study is small and does not validate every broad label claim. Confirm the parasite and reassess response rather than treating label breadth as proof of coverage.
  • Fipronil is highly toxic to aquatic invertebrates and the label states toxicity to fish and bees; prevent entry into surface water and dispose of pipettes responsibly.
Assessment sources
  1. Vetsintez Perfect Trio
  2. Georgia NFA register 20262026
  3. Perfect Trio field study2024
  4. ESCCAP ectoparasite guideline2024
  5. ESCCAP worm control guideline2026
  6. AHS canine heartworm guidelines2024
  7. EMA ectoparasiticide environment 20232023
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil100 mg/ml Ivermectin15 mg/ml Pyriproxyfen20 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Vetsintez LLC · Ukraine
Manufacturer (register)
Vetsintez LLC, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1323, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000804
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
0.8 ml (0.8 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 Dog 4–10 kg On the skin apply one complete pipette once; repeat only as directed
Vetsintez Perfect Trio
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Perfect Trio spot-on - current official dog and cat instructions
Vetsintez official veterinary product instructions
100/15/20 mg/ml spot-on, Spot-on · Dog 10–20 kg Dog 10–20 kg 1.6 ml (1.6 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 · apply one complete pipette once; repeat only as directed		 apply one complete pipette once; repeat only as directed Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000801
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Perfect Trio 100/15/20 mg/ml spot-on, Spot-on

1.6 ml N3 for dogs 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.7/10
Weak evidence support
vetman assessment

Perfect Trio

100/15/20 mg/ml spot-on, 1.6 ml N3 for dogs 10-20 kg
Assessed clinical scopeDog · Full labelled canine topical scope in the exact weight band: fleas, lice, biting lice, mosquitoes, ticks and mites; gastrointestinal nematodes; Dirofilaria larval prevention · On the skin
Care settingVeterinary-selected home spot-on use after parasite identification and heartworm-risk assessment, with follow-up for established infestation or infection
vetman score 5.7/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000801 · Verified on 21 Oct 2026

Locally registered exact spot-on with a positive but small exact-product field study. It may be a situational broad-spectrum option after parasite selection, but its wide claims and safety margin are less securely documented than better-studied alternatives; avoid MDR1-susceptible dogs and use the exact weight band.

Regulatory and scientific credibility6.0/10

The exact presentation is actively registered in Georgia, current official manufacturer instructions verify its composition and labelled use, and an exact-product peer-reviewed field study is available. However, no EMA/FDA-style public assessment, regulator-hosted SPC or transparent full dossier for this formulation was found.

Clinical efficacy6.0/10

A 2024 exact-product field study reported high efficacy in naturally infested dogs and cats against selected fleas, lice and mites, plus feline Uncinaria, with one-month follow-up. Each parasite group contained only seven animals, the comparator and blinding are inadequately reported, and many broad label targets and prevention claims were not tested.

Safety and tolerability4.5/10

The small field study reported no adverse effects, but it cannot establish a broad safety margin or detect uncommon events. The label prohibits use in pregnancy, lactation, young, underweight, sick or convalescent animals and specifically warns against use in MDR1-mutant breeds because of possible neurotoxicity.

Clinical practicality6.5/10

A whole weight-banded pipette makes routine dosing straightforward, but treatment varies by target: one application, repeated 7-10-day courses for some mites, or monthly heartworm prevention. Correct skin placement, prevention of licking, bathing restrictions, ear examination when relevant and follow-up add meaningful clinical and adherence burden.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with hypersensitivity, in animals under 3 months or at or below 2 kg, or in sick, convalescent, debilitated or emaciated patients.
  • Do not use during pregnancy or lactation; the exact combination does not have an established reproductive safety margin.
  • Do not combine with another macrocyclic lactone or antiparasitic unless a veterinarian has checked active ingredients, intervals and cumulative neurotoxicity.
  • The label does not recommend use in Collies, Shetland Sheepdogs, Old English Sheepdogs, Scottish Shepherds or their crosses because of possible MDR1-associated neurotoxicity.
  • Prevent licking and separate treated animals until dry. Monitor for local irritation, hypersalivation, vomiting, depression, ataxia, tremor or other neurologic signs; wash off and assess promptly if they occur.
  • Apply the entire exact pipette directly to dry intact skin. Do not bathe for 3 days before or after treatment and avoid handling or contact with small children for 48 hours.
  • For ear-mite treatment, examine and clean the ear first and confirm tympanic-membrane integrity; complicated otitis requires separate diagnosis and treatment.
  • Heartworm use is prevention against susceptible larval stages, not adulticide treatment. Assess exposure and infection status and follow current species-specific guidance.
  • The exact-product study is small and does not validate every broad label claim. Confirm the parasite and reassess response rather than treating label breadth as proof of coverage.
  • Fipronil is highly toxic to aquatic invertebrates and the label states toxicity to fish and bees; prevent entry into surface water and dispose of pipettes responsibly.
Assessment sources
  1. Vetsintez Perfect Trio
  2. Georgia NFA register 20262026
  3. Perfect Trio field study2024
  4. ESCCAP ectoparasite guideline2024
  5. ESCCAP worm control guideline2026
  6. AHS canine heartworm guidelines2024
  7. EMA ectoparasiticide environment 20232023
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil100 mg/ml Ivermectin15 mg/ml Pyriproxyfen20 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Vetsintez LLC · Ukraine
Manufacturer (register)
Vetsintez LLC, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1319, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 11 Nov 2029
Veterinary (National Food Agency)
In the register: პერფექტ ტრიო
№ 000801
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
1.6 ml (1.6 ml)
Apply to dry, intact skin where licking is prevented. Do not use in sick, recovering or debilitated animals. Separate animals until dry; do not bathe for 3 days before or after treatment and keep children from handling the animal for 48 hours.
 Dog 10–20 kg On the skin apply one complete pipette once; repeat only as directed
Vetsintez Perfect Trio
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Perfect Trio spot-on - current official dog and cat instructions
Vetsintez official veterinary product instructions
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Pyriproxyfen
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
2 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 67 mg/20 mg Spot-on Solution for Small Dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
10 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Ivermectin: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD
  • Critical Pyriproxyfen
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Caution Pyriproxyfen
    Laboratory studies in dogs have not produced any evidence of teratogenic or embryotoxic effects. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Caution Pyriproxyfen
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Known Breed Sensitivities Ivermectin
    Collie, Collie (unspecified), Collie - Scottish Rough, Collie - Scottish Smooth, Sheepdog - Old English, Sheepdog - Shetland (Sheltie), Shetland Sheepdog
    Ivermectin: collies and related herding breeds with the MDR1 (ABCB1) deletion are sensitive to it. The heartworm-prevention dose (6 µg/kg) is tolerated; higher doses (the label: more than 16 times that) can cause dilated pupils, unsteadiness, tremors, coma and death. Give antiparasitic doses only to a dog tested MDR1 normal.

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