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Dironet 1000

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Pyrantel + Praziquantel + Ivermectin · AVZ S-P Ltd

1 form: scored tablet. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Form Species Dose Frequency Georgia
450/150/0.18 mg tablets, Scored tablet · Dog Dog Gastrointestinal Nematode and Cestode Infection · By mouth: 1 tablet per 30 kgMicrofilaria Reduction · By mouth: 1 tablet per 30 kgHeartworm Prevention · By mouth: 1 tablet per 30 kg - Georgia Yes, veterinary
In force until 06 Sep 2029
Veterinary (National Food Agency)
In the register: დირონეტი 1000
№ 000696
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Dironet 1000 450/150/0.18 mg tablets, Scored tablet

N6 for large dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.7/10
Weak evidence support
vetman assessment

Dironet 1000

450/150/0.18 mg tablets, N6 for large dogs
Assessed clinical scopeDog · Full dog label for large dogs: single treatment of gastrointestinal roundworms and tapeworms, monthly reduction of Dirofilaria immitis and D. repens microfilariae, and seasonal monthly heartworm prevention with ivermectin · By mouth
Care settingVeterinary-directed deworming and heartworm prevention of a weighed dog after a negative heartworm test and breed check
vetman score 5.7/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000696 · Verified on 21 Oct 2026

A weak option: a convenient dewormer with heartworm prevention, but it has no whipworm cover and only manufacturer evidence, and it needs a heartworm test and MDR1 caution before use.

Regulatory and scientific credibility4.5/10

The exact presentation is registered in Georgia (000696, valid to 2029) with a 2017 Russian manufacturer instruction, but no EU, UK or US authorisation was documented in the reviewed evidence and no product-specific study.

Clinical efficacy6.0/10

Praziquantel and pyrantel are well supported against tapeworms, Toxocara and hookworms, and low-dose monthly ivermectin is an established heartworm preventive; no component treats Trichuris, and product-level evidence is not public.

Safety and tolerability6.0/10

Preventive-dose ivermectin is generally tolerated, but in heartworm-positive dogs with many microfilariae it can trigger shock-like reactions, and MDR1-mutant breeds need supervision; pregnancy and lactation are excluded.

Clinical practicality6.5/10

A scored tablet with the morning feed and no fasting is practical, but heartworm prevention needs monthly dosing through the mosquito season and a test before starting.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Test for heartworm (antigen and microfilariae) before starting: in heartworm-positive dogs macrocyclic lactones can cause shock-like reactions, and this product does not kill adult worms.
  • Collies, Shelties, Australian Shepherds and other MDR1-mutant breeds: use only under veterinary supervision, never exceed the dose, and consider MDR1 genotyping.
  • Do not use in pregnant or lactating bitches, puppies under 3 weeks, or together with another anthelmintic.
  • No activity against Trichuris whipworms.
  • For prevention, give monthly from before the mosquito season until one month after it ends, and retest for heartworm yearly.
Assessment sources
  1. Dironet label2017
  2. Georgia NFA register 20262026
  3. ESCCAP worm control guideline2026
  4. ESCCAP GL5 vector-borne diseases2026
  5. AHS canine heartworm guidelines2024
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Pyrantel450 mg/tablet Praziquantel150 mg/tablet Ivermectin0.18 mg/tablet
Formulation Type
Scored tablet
Administration route
By mouth
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1184, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 06 Sep 2029
Veterinary (National Food Agency)
In the register: დირონეტი 1000
№ 000696
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
Dog
WeightGastrointestinal Nematode and Cestode Infection · By mouthMicrofilaria Reduction · By mouthHeartworm Prevention · By mouth
Any weight 1 tablet per 30 kg 1 tablet per 30 kg 1 tablet per 30 kg
  • Gastrointestinal Nematode and Cestode Infection · By mouth (once): Give once with the morning feed. Routine deworming is quarterly and before vaccination. No fasting or laxative is required. Do not use under 0.5 kg, under 3 weeks, during pregnancy/lactation or with hypersensitivity. Macrocyclic-lactone-sensitive breeds require veterinary supervision. Do not combine with another anthelmintic.
  • Microfilaria Reduction · By mouth (monthly): Give one therapeutic dose once monthly to reduce circulating Dirofilaria immitis or D. repens microfilariae. Follow all product restrictions, including veterinary supervision for macrocyclic-lactone-sensitive breeds.
  • Heartworm Prevention · By mouth (monthly): Begin before mosquito season, continue monthly throughout the season and give the final dose one month after mosquito season ends. This is a preventive regimen, not adulticide treatment.
Source:
Dironet label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Dironet 200/500/1000 tablets - regulator-approved veterinary instruction
Regulator-approved veterinary instruction, 2017
Active substance doses, with sources
Active substance Pyrantel
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
14.4 mg/kg Dog Maintenance By mouth once
VMD SPC 2022
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Multiwormer 50/144/150 mg tablets for dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2022
20 mg/kg Cat Maintenance By mouth once
VMD SPC 2024
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Wormer 230 mg/20 mg film-coated tablets for cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2024
Active substance Praziquantel
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
5 mg/kg Dog, Cat Maintenance By mouth once
VMD SPC 2022
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Multiwormer 50/144/150 mg tablets for dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2022
VMD SPC 2024
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Wormer 230 mg/20 mg film-coated tablets for cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2024

Ivermectin: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Praziquantel
    Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Pyrantel (Dog)
    Do not use in dogs younger than 2 weeks of age and/or weighing less than 2 kg.
    Sources: VMD SPC · VMD · FDA
  • Known Breed Sensitivities Ivermectin
    Collie, Collie (unspecified), Collie - Scottish Rough, Collie - Scottish Smooth, Sheepdog - Old English, Sheepdog - Shetland (Sheltie), Shetland Sheepdog
    Ivermectin: collies and related herding breeds with the MDR1 (ABCB1) deletion are sensitive to it. The heartworm-prevention dose (6 µg/kg) is tolerated; higher doses (the label: more than 16 times that) can cause dilated pupils, unsteadiness, tremors, coma and death. Give antiparasitic doses only to a dog tested MDR1 normal.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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