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Imidacloprid + Moxidectin · Elanco

3 forms: spot-on. In force in Georgia: 3 of 3 (veterinary register).

Forms and doses3 of 3 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
40 mg/4 mg, Spot-on · Cat up to 4 kg Cat up to 4 kg 1 pipette
≤ 4 kg; Advocate for small cats; 0.4; minimum of 10; minimum of 1
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი 4კგ–მდე კატებისათვის
№ 20-11
Verified on: 15 Oct 2026
40 mg/4 mg, Spot-on · Dog Any weight Dog Any weight No dose for this species
Do not use this feline imidacloprid/moxidectin product in dogs. Use the corresponding canine product selected by body weight.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი 4კგ–მდე კატებისათვის
№ 20-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advocate 40 mg/4 mg, Spot-on

imidacloprid 40 mg + moxidectin 4 mg, spot-on solution for cats up to 4 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.6/10
Very good
vetman assessment

Advocate

40 mg/4 mg, imidacloprid 40 mg + moxidectin 4 mg, spot-on solution for cats up to 4 kg
Assessed clinical scopeCat · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.6/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 20-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide with strong regulatory and clinical support; its wide label does not remove the need for exact species, concentration and heartworm-risk selection.

Regulatory and scientific credibility9.5/10

The exact presentation is registered in Georgia and belongs to the mature centrally authorised EU Advocate line, with matching current UK and FDA counterpart documentation.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below nine weeks of age. A cat below 1 kg, or a sick, debilitated or underweight cat, requires the strictest applicable label and a veterinarian-led benefit-risk decision.
  • Establish heartworm status and exact indication before use: applicable EU and FDA labels differ on heartworm-positive cats, and adult infection may carry severe risk.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi cat FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid40 mg Moxidectin4 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Manufacturer (register)
KVP Pharma + Veterinär Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 59, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი 4კგ–მდე კატებისათვის
№ 20-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
≤ 4 kg; Advocate for small cats; 0.4; minimum of 10; minimum of 1
 Cat up to 4 kg On the skin monthly Product label (SPC)
No dose for this species
Do not use this feline imidacloprid/moxidectin product in dogs. Use the corresponding canine product selected by body weight.
 Dog Any weight On the skin - Product label (SPC)
80 mg/8 mg, Spot-on · Cat 4–8 kg Cat 4–8 kg 1 pipette
> 4-8 kg; Advocate for large cats; 0.8; 10-20; 1-2 > 8 kg; the appropriate combination of pipettes
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი
№ 34-11
Verified on: 15 Oct 2026
80 mg/8 mg, Spot-on · Dog Any weight Dog Any weight No dose for this species
Do not use this feline product in dogs.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი
№ 34-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advocate 80 mg/8 mg, Spot-on

imidacloprid 80 mg + moxidectin 8 mg, spot-on solution for cats 4-8 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

Advocate

80 mg/8 mg, imidacloprid 80 mg + moxidectin 8 mg, spot-on solution for cats 4-8 kg
Assessed clinical scopeCat · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 34-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide with strong regulatory and clinical support; its wide label does not remove the need for exact species, concentration and heartworm-risk selection.

Regulatory and scientific credibility9.0/10

The exact 80/8 mg presentation is mature and currently authorised in Europe, but the historical Georgian register row names Advocate while listing imidacloprid alone, so the local composition record is internally incomplete.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below nine weeks of age. A cat below 1 kg, or a sick, debilitated or underweight cat, requires the strictest applicable label and a veterinarian-led benefit-risk decision.
  • Establish heartworm status and exact indication before use: applicable EU and FDA labels differ on heartworm-positive cats, and adult infection may carry severe risk.
  • The Georgian historical row for Advocate 80/8 mg names Advocate but lists imidacloprid alone; verify the physical pack contains both imidacloprid 80 mg and moxidectin 8 mg before use.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi cat FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid80 mg Moxidectin8 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი
№ 34-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
> 4-8 kg; Advocate for large cats; 0.8; 10-20; 1-2 > 8 kg; the appropriate combination of pipettes
 Cat 4–8 kg On the skin monthly Product label (SPC)
No dose for this species
Do not use this feline product in dogs.
 Dog Any weight On the skin - Product label (SPC)
400 mg/100 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this canine imidacloprid/moxidectin product in cats. Use the corresponding feline 0.4 mL or 0.8 mL product selected by body weight.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი 25-40 კგ ძაღლებისათვის
№ 19-11
Verified on: 15 Oct 2026
400 mg/100 mg, Spot-on · Dog 25–40 kg Dog 25–40 kg 1 pipette
> 25-40 kg; Advocate for extra-large dogs; 4.0; 10-16; 2.5-4 > 40 kg; the appropriate combination of pipettes Do not use in cats.
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი 25-40 კგ ძაღლებისათვის
№ 19-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advocate 400 mg/100 mg, Spot-on

imidacloprid 400 mg + moxidectin 100 mg, spot-on solution for dogs 25-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.6/10
Very good
vetman assessment

Advocate

400 mg/100 mg, imidacloprid 400 mg + moxidectin 100 mg, spot-on solution for dogs 25-40 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.6/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 19-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide with strong regulatory and clinical support; its wide label does not remove the need for exact species, concentration and heartworm-risk selection.

Regulatory and scientific credibility9.5/10

The exact presentation is registered in Georgia and belongs to the mature centrally authorised EU Advocate line, with matching current UK and FDA counterpart documentation.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below seven weeks of age; animals below 1 kg, or sick, debilitated or underweight dogs, require the exact label and an explicit benefit-risk decision.
  • Before heartworm use, establish infection status and clinical class. Class 4 disease is contraindicated or unevaluated by the applicable labels; microfilariae treatment and MDR1-sensitive breeds require strict observation for neurologic or acute reactions.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi dog FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid400 mg Moxidectin100 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვოკატი 25-40 კგ ძაღლებისათვის
№ 19-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this canine imidacloprid/moxidectin product in cats. Use the corresponding feline 0.4 mL or 0.8 mL product selected by body weight.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
> 25-40 kg; Advocate for extra-large dogs; 4.0; 10-16; 2.5-4 > 40 kg; the appropriate combination of pipettes Do not use in cats.
 Dog 25–40 kg On the skin monthly Product label (SPC)
Active substance doses, with sources
Active substance Imidacloprid
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
10–25 mg/kg Dog Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 400 mg + 100 mg spot-on solution for extra-large dogs (> 25-40 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
10–20 mg/kg Cat Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 40 mg + 4 mg spot-on solution for small cats (<= 4 kg) and ferrets - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Moxidectin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
2.5–6.25 mg/kg Dog Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 400 mg + 100 mg spot-on solution for extra-large dogs (> 25-40 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
1–2 mg/kg Cat Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 40 mg + 4 mg spot-on solution for small cats (<= 4 kg) and ferrets - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical Imidacloprid
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Moxidectin
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Moxidectin (Dog)
    Do not use in puppies under 7 weeks of age. The safe use... has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. body weight.
    Sources: VMD SPC · VMD · FDA
  • Critical Moxidectin (Cat)
    Do not use in kittens under 9 weeks of age. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation in the target species.... The use is not recommended during pregnancy and lactation. Fertility: Do not use in breeding animals. The safety... has not been established in breeding, pregnant, or lactating
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin
    The use is not recommended during pregnancy and lactation.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Dog)
    special care should be taken with Collie or Old English Sheep dogs and related breeds or crossbreeds... in particular, oral uptake by Collie or Old English Sheep dogs and related breeds or crossbreeds should be prevented. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. The most common breeds associated with this mutation include Collies and Collie crosses.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Dog)
    Do not use in dogs classified as Class 4 for heartworm disease has not been evaluated in heartworm-positive dogs with Class 4 heartworm disease
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Cat)
    use of the veterinary medicinal product on cats or ferrets which have adult heartworms may cause serious adverse effects, including death No adverse reactions were associated with the topical application... to experimentally heartworm-infected cats.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Cat)
    Do not use on sick, debilitated, or underweight cats Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.
    Sources: VMD SPC · VMD · FDA
  • Caution Moxidectin (Dog)
    Use with caution in sick, debilitated, or underweight animals.
    Sources: VMD SPC · VMD · FDA
  • Known Breed Sensitivities Moxidectin
    Collie, Collie (unspecified), Collie - Scottish Rough, Collie - Scottish Smooth, Sheepdog - Old English
    special care should be taken with Collie or Old English Sheep dogs and related breeds or crossbreeds... oral uptake... should be prevented.

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

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Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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