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Imidacloprid + Permethrin · KVP Pharma + Veterinar Produkte GmbH

5 forms: spot-on. In force in Georgia: 5 of 5 (veterinary register).

Do not use on cats. Prevent cats from contacting or grooming a treated dog; follow the exact label for the separation period. Species safety: cats →

Forms and doses5 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Enter weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
40 mg + 200 mg, Spot-on · Dog 1.5–4 kg Dog 1.5–4 kg 1 pipette (0.4 ml)
Apply one whole 0.4 ml pipette to intact skin. Apply at one point between the shoulder blades. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Do not repeat more often than weekly after frequent water exposure.
 · Based on epidemiology and lifestyle; flea protection lasts 4 weeks		 Based on epidemiology and lifestyle; flea protection lasts 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 4 კგ-მდე ძაღლებისათვის
№ 314-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Advantix 40 mg + 200 mg, Spot-on

imidacloprid 40 mg + permethrin 200 mg, spot-on solution for dogs up to 4 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.0/10
Very good
vetman assessment

Advantix

40 mg + 200 mg, imidacloprid 40 mg + permethrin 200 mg, spot-on solution for dogs up to 4 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope: treatment and prevention of flea, tick and biting-louse infestations plus repellent activity against specified ticks, sand flies, mosquitoes and stable flies · On the skin
Care settingVeterinary-selected outpatient ectoparasite control based on local epidemiology and household species
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 314-11 · Verified on 21 Oct 2026

A broad and well-supported dog-only ectoparasite option with valuable repellency; household cat safety and exact weight-band application are non-negotiable.

Regulatory and scientific credibility9.0/10

The five exact strengths have current official SPC coverage and active Georgian veterinary registrations with exact authorisation numbers; independent field evidence is available.

Clinical efficacy8.5/10

The combination provides strong flea and tick control plus clinically useful repellent activity against multiple vectors, supported by field studies; duration and performance vary by parasite species, exposure and wetting.

Safety and tolerability6.5/10

Canine tolerability is generally good, but permethrin exposure can be fatal to cats; transient skin, behavioural, gastrointestinal and rare neurologic reactions are recognised, and the product is highly hazardous to aquatic organisms.

Clinical practicality8.0/10

A weight-banded pipette gives roughly monthly protection, but correct multi-spot skin application, drying, temporary separation from cats, bathing constraints and epidemiology-based retreatment require more technique than a simple oral dose.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats: permethrin is extremely poisonous and exposure can be fatal. Keep treated dogs away from cats until the application site is dry and seek veterinary help immediately after accidental feline exposure.
  • Do not allow treated dogs into surface water for 48 hours; the product is highly toxic to aquatic organisms.
  • Use the exact pipette for the dog's weight band and apply directly to intact skin at the labelled number of sites; do not use below the presentation's minimum weight or under seven weeks of age.
  • Choose retreatment by local epidemiology and lifestyle; frequent shampooing or water exposure may reduce persistence, and treated animals should not groom one another before drying.
Assessment sources
  1. VMD SPC 20262026
  2. European tick field RCT2016
  3. Vector-borne disease field study2010
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid40 mg Permethrin200 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1225, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 4 კგ-მდე ძაღლებისათვის
№ 314-11
Verified on: 21 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette (0.4 ml)
Apply one whole 0.4 ml pipette to intact skin. Apply at one point between the shoulder blades. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Do not repeat more often than weekly after frequent water exposure.
 Dog 1.5–4 kg On the skin Based on epidemiology and lifestyle; flea protection lasts 4 weeks
VMD Advantix 2026
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40/200, 100/500, 250/1250, 400/2000 and 600/3000 mg spot-on solutions - package leaflet
UK Veterinary Medicines Directorate, 2026
100 mg + 500 mg, Spot-on · Dog 4–10 kg Dog 4–10 kg 1 pipette (1 ml)
Apply one whole 1.0 ml pipette to intact skin. Apply at one point between the shoulder blades. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Do not repeat more often than weekly after frequent water exposure.
 · Based on epidemiology and lifestyle; flea protection lasts 4 weeks		 Based on epidemiology and lifestyle; flea protection lasts 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 4-10 კგ ძაღლებისათვის
№ 317-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Advantix 100 mg + 500 mg, Spot-on

imidacloprid 100 mg + permethrin 500 mg, spot-on solution for dogs 4-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.0/10
Very good
vetman assessment

Advantix

100 mg + 500 mg, imidacloprid 100 mg + permethrin 500 mg, spot-on solution for dogs 4-10 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope: treatment and prevention of flea, tick and biting-louse infestations plus repellent activity against specified ticks, sand flies, mosquitoes and stable flies · On the skin
Care settingVeterinary-selected outpatient ectoparasite control based on local epidemiology and household species
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 317-11 · Verified on 21 Oct 2026

A broad and well-supported dog-only ectoparasite option with valuable repellency; household cat safety and exact weight-band application are non-negotiable.

Regulatory and scientific credibility9.0/10

The five exact strengths have current official SPC coverage and active Georgian veterinary registrations with exact authorisation numbers; independent field evidence is available.

Clinical efficacy8.5/10

The combination provides strong flea and tick control plus clinically useful repellent activity against multiple vectors, supported by field studies; duration and performance vary by parasite species, exposure and wetting.

Safety and tolerability6.5/10

Canine tolerability is generally good, but permethrin exposure can be fatal to cats; transient skin, behavioural, gastrointestinal and rare neurologic reactions are recognised, and the product is highly hazardous to aquatic organisms.

Clinical practicality8.0/10

A weight-banded pipette gives roughly monthly protection, but correct multi-spot skin application, drying, temporary separation from cats, bathing constraints and epidemiology-based retreatment require more technique than a simple oral dose.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats: permethrin is extremely poisonous and exposure can be fatal. Keep treated dogs away from cats until the application site is dry and seek veterinary help immediately after accidental feline exposure.
  • Do not allow treated dogs into surface water for 48 hours; the product is highly toxic to aquatic organisms.
  • Use the exact pipette for the dog's weight band and apply directly to intact skin at the labelled number of sites; do not use below the presentation's minimum weight or under seven weeks of age.
  • Choose retreatment by local epidemiology and lifestyle; frequent shampooing or water exposure may reduce persistence, and treated animals should not groom one another before drying.
Assessment sources
  1. VMD SPC 20262026
  2. European tick field RCT2016
  3. Vector-borne disease field study2010
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid100 mg Permethrin500 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1227, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 4-10 კგ ძაღლებისათვის
№ 317-11
Verified on: 21 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette (1 ml)
Apply one whole 1.0 ml pipette to intact skin. Apply at one point between the shoulder blades. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Do not repeat more often than weekly after frequent water exposure.
 Dog 4–10 kg On the skin Based on epidemiology and lifestyle; flea protection lasts 4 weeks
VMD Advantix 2026
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40/200, 100/500, 250/1250, 400/2000 and 600/3000 mg spot-on solutions - package leaflet
UK Veterinary Medicines Directorate, 2026
250 mg + 1250 mg, Spot-on · Dog 10–25 kg Dog 10–25 kg 1 pipette (2.5 ml)
Apply one whole 2.5 ml pipette to intact skin. Apply the entire pipette evenly at four points along the back, from shoulder to tail base. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Pregnant women must not administer it; women of childbearing age should wear gloves. Do not repeat more often than weekly after frequent water exposure.
 · Based on epidemiology and lifestyle; flea protection lasts 4 weeks		 Based on epidemiology and lifestyle; flea protection lasts 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 10-25 კგ ძაღლებისათვის
№ 315-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Advantix 250 mg + 1250 mg, Spot-on

imidacloprid 250 mg + permethrin 1250 mg, spot-on solution for dogs 10-25 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.0/10
Very good
vetman assessment

Advantix

250 mg + 1250 mg, imidacloprid 250 mg + permethrin 1250 mg, spot-on solution for dogs 10-25 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope: treatment and prevention of flea, tick and biting-louse infestations plus repellent activity against specified ticks, sand flies, mosquitoes and stable flies · On the skin
Care settingVeterinary-selected outpatient ectoparasite control based on local epidemiology and household species
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 315-11 · Verified on 21 Oct 2026

A broad and well-supported dog-only ectoparasite option with valuable repellency; household cat safety and exact weight-band application are non-negotiable.

Regulatory and scientific credibility9.0/10

The five exact strengths have current official SPC coverage and active Georgian veterinary registrations with exact authorisation numbers; independent field evidence is available.

Clinical efficacy8.5/10

The combination provides strong flea and tick control plus clinically useful repellent activity against multiple vectors, supported by field studies; duration and performance vary by parasite species, exposure and wetting.

Safety and tolerability6.5/10

Canine tolerability is generally good, but permethrin exposure can be fatal to cats; transient skin, behavioural, gastrointestinal and rare neurologic reactions are recognised, and the product is highly hazardous to aquatic organisms.

Clinical practicality8.0/10

A weight-banded pipette gives roughly monthly protection, but correct multi-spot skin application, drying, temporary separation from cats, bathing constraints and epidemiology-based retreatment require more technique than a simple oral dose.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats: permethrin is extremely poisonous and exposure can be fatal. Keep treated dogs away from cats until the application site is dry and seek veterinary help immediately after accidental feline exposure.
  • Do not allow treated dogs into surface water for 48 hours; the product is highly toxic to aquatic organisms.
  • Use the exact pipette for the dog's weight band and apply directly to intact skin at the labelled number of sites; do not use below the presentation's minimum weight or under seven weeks of age.
  • Choose retreatment by local epidemiology and lifestyle; frequent shampooing or water exposure may reduce persistence, and treated animals should not groom one another before drying.
Assessment sources
  1. VMD SPC 20262026
  2. European tick field RCT2016
  3. Vector-borne disease field study2010
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid250 mg Permethrin1250 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1226, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 10-25 კგ ძაღლებისათვის
№ 315-11
Verified on: 21 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette (2.5 ml)
Apply one whole 2.5 ml pipette to intact skin. Apply the entire pipette evenly at four points along the back, from shoulder to tail base. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Pregnant women must not administer it; women of childbearing age should wear gloves. Do not repeat more often than weekly after frequent water exposure.
 Dog 10–25 kg On the skin Based on epidemiology and lifestyle; flea protection lasts 4 weeks
VMD Advantix 2026
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40/200, 100/500, 250/1250, 400/2000 and 600/3000 mg spot-on solutions - package leaflet
UK Veterinary Medicines Directorate, 2026
400 mg + 2000 mg, Spot-on · Dog 25–40 kg Dog 25–40 kg 1 pipette (4 ml)
Apply one whole 4.0 ml pipette to intact skin. Apply the entire pipette evenly at four points along the back, from shoulder to tail base. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Pregnant women must not administer it; women of childbearing age should wear gloves. Do not repeat more often than weekly after frequent water exposure.
 · Based on epidemiology and lifestyle; flea protection lasts 4 weeks		 Based on epidemiology and lifestyle; flea protection lasts 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 25-40 კგ ძაღლებისათვის
№ 312-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Advantix 400 mg + 2000 mg, Spot-on

imidacloprid 400 mg + permethrin 2000 mg, spot-on solution for dogs 25-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.0/10
Very good
vetman assessment

Advantix

400 mg + 2000 mg, imidacloprid 400 mg + permethrin 2000 mg, spot-on solution for dogs 25-40 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope: treatment and prevention of flea, tick and biting-louse infestations plus repellent activity against specified ticks, sand flies, mosquitoes and stable flies · On the skin
Care settingVeterinary-selected outpatient ectoparasite control based on local epidemiology and household species
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 312-11 · Verified on 21 Oct 2026

A broad and well-supported dog-only ectoparasite option with valuable repellency; household cat safety and exact weight-band application are non-negotiable.

Regulatory and scientific credibility9.0/10

The five exact strengths have current official SPC coverage and active Georgian veterinary registrations with exact authorisation numbers; independent field evidence is available.

Clinical efficacy8.5/10

The combination provides strong flea and tick control plus clinically useful repellent activity against multiple vectors, supported by field studies; duration and performance vary by parasite species, exposure and wetting.

Safety and tolerability6.5/10

Canine tolerability is generally good, but permethrin exposure can be fatal to cats; transient skin, behavioural, gastrointestinal and rare neurologic reactions are recognised, and the product is highly hazardous to aquatic organisms.

Clinical practicality8.0/10

A weight-banded pipette gives roughly monthly protection, but correct multi-spot skin application, drying, temporary separation from cats, bathing constraints and epidemiology-based retreatment require more technique than a simple oral dose.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats: permethrin is extremely poisonous and exposure can be fatal. Keep treated dogs away from cats until the application site is dry and seek veterinary help immediately after accidental feline exposure.
  • Do not allow treated dogs into surface water for 48 hours; the product is highly toxic to aquatic organisms.
  • Use the exact pipette for the dog's weight band and apply directly to intact skin at the labelled number of sites; do not use below the presentation's minimum weight or under seven weeks of age.
  • Choose retreatment by local epidemiology and lifestyle; frequent shampooing or water exposure may reduce persistence, and treated animals should not groom one another before drying.
Assessment sources
  1. VMD SPC 20262026
  2. European tick field RCT2016
  3. Vector-borne disease field study2010
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid400 mg Permethrin2000 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1223, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 25-40 კგ ძაღლებისათვის
№ 312-11
Verified on: 21 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette (4 ml)
Apply one whole 4.0 ml pipette to intact skin. Apply the entire pipette evenly at four points along the back, from shoulder to tail base. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Pregnant women must not administer it; women of childbearing age should wear gloves. Do not repeat more often than weekly after frequent water exposure.
 Dog 25–40 kg On the skin Based on epidemiology and lifestyle; flea protection lasts 4 weeks
VMD Advantix 2026
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40/200, 100/500, 250/1250, 400/2000 and 600/3000 mg spot-on solutions - package leaflet
UK Veterinary Medicines Directorate, 2026
600 mg + 3000 mg, Spot-on · Dog 40–60 kg Dog 40–60 kg 1 pipette (6 ml)
Apply one whole 6.0 ml pipette to intact skin. Apply the entire pipette evenly at four points along the back, from shoulder to tail base. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Pregnant women must not administer it; women of childbearing age should wear gloves. Do not repeat more often than weekly after frequent water exposure.
 · Based on epidemiology and lifestyle; flea protection lasts 4 weeks		 Based on epidemiology and lifestyle; flea protection lasts 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 40-60 კგ ძაღლებისათვის
№ 311-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Advantix 600 mg + 3000 mg, Spot-on

imidacloprid 600 mg + permethrin 3000 mg, spot-on solution for dogs 40-60 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.0/10
Very good
vetman assessment

Advantix

600 mg + 3000 mg, imidacloprid 600 mg + permethrin 3000 mg, spot-on solution for dogs 40-60 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope: treatment and prevention of flea, tick and biting-louse infestations plus repellent activity against specified ticks, sand flies, mosquitoes and stable flies · On the skin
Care settingVeterinary-selected outpatient ectoparasite control based on local epidemiology and household species
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 311-11 · Verified on 21 Oct 2026

A broad and well-supported dog-only ectoparasite option with valuable repellency; household cat safety and exact weight-band application are non-negotiable.

Regulatory and scientific credibility9.0/10

The five exact strengths have current official SPC coverage and active Georgian veterinary registrations with exact authorisation numbers; independent field evidence is available.

Clinical efficacy8.5/10

The combination provides strong flea and tick control plus clinically useful repellent activity against multiple vectors, supported by field studies; duration and performance vary by parasite species, exposure and wetting.

Safety and tolerability6.5/10

Canine tolerability is generally good, but permethrin exposure can be fatal to cats; transient skin, behavioural, gastrointestinal and rare neurologic reactions are recognised, and the product is highly hazardous to aquatic organisms.

Clinical practicality8.0/10

A weight-banded pipette gives roughly monthly protection, but correct multi-spot skin application, drying, temporary separation from cats, bathing constraints and epidemiology-based retreatment require more technique than a simple oral dose.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats: permethrin is extremely poisonous and exposure can be fatal. Keep treated dogs away from cats until the application site is dry and seek veterinary help immediately after accidental feline exposure.
  • Do not allow treated dogs into surface water for 48 hours; the product is highly toxic to aquatic organisms.
  • Use the exact pipette for the dog's weight band and apply directly to intact skin at the labelled number of sites; do not use below the presentation's minimum weight or under seven weeks of age.
  • Choose retreatment by local epidemiology and lifestyle; frequent shampooing or water exposure may reduce persistence, and treated animals should not groom one another before drying.
Assessment sources
  1. VMD SPC 20262026
  2. European tick field RCT2016
  3. Vector-borne disease field study2010
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid600 mg Permethrin3000 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1222, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტიქსი™ 40-60 კგ ძაღლებისათვის
№ 311-11
Verified on: 21 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette (6 ml)
Apply one whole 6.0 ml pipette to intact skin. Apply the entire pipette evenly at four points along the back, from shoulder to tail base. Do not use in puppies under 7 weeks or under 1.5 kg. Do not use on cats: permethrin exposure may be fatal; keep treated dogs away from cats until the site is dry. Avoid eyes, mouth and licking. Keep out of surface water for 48 hours. Pregnant women must not administer it; women of childbearing age should wear gloves. Do not repeat more often than weekly after frequent water exposure.
 Dog 40–60 kg On the skin Based on epidemiology and lifestyle; flea protection lasts 4 weeks
VMD Advantix 2026
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40/200, 100/500, 250/1250, 400/2000 and 600/3000 mg spot-on solutions - package leaflet
UK Veterinary Medicines Directorate, 2026
Active substance doses, with sources
Active substance Imidacloprid
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
10–25 mg/kg Dog Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 400 mg + 100 mg spot-on solution for extra-large dogs (> 25-40 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
10–20 mg/kg Cat Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 40 mg + 4 mg spot-on solution for small cats (<= 4 kg) and ferrets - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Permethrin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
50 mg/kg Dog Maintenance On the skin according to the epidemiological situation
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40 mg + 200 mg spot-on solution for dogs (<= 4 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
60 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effitix 26.8 mg/240 mg spot-on solution for very small dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical Imidacloprid
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Permethrin
    Do not use in cases of hypersensitivity to the active substances, or to any of the excipients.
    Sources: VMD SPC · VMD
  • Warning Permethrin (Dog)
    In the absence of available data the veterinary medicinal product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight. The safety of the product has not been established in dogs younger than 12 weeks of age or in dogs weighing less than 1.5 kg.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. The safety of the veterinary medicinal product has not been established in dogs during pregnancy, lactation or in animals intended for breeding. Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone have shown evidence of foetotoxic effects. Use only according to the benefit-risk assessment by the responsible veterinarian. The safety of the veterinary medicinal product has not been established during pregnancy and lactation in bitches. Use in pregnancy and lactation only in accordance with professional veterinary advice and a benefit/risk assessment.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD

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