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Milbemycin oxime + Arpraziquantel · Astrafarm

5 forms: tablet. No registration in force in Georgia.

Forms and doses0 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Tablet · Cat Any weight Cat Any weight No dose for this species
This tablet is for dogs; no feline dose is provided in the instructions.
 - Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 5კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002533
Verified on: 15 Oct 2026
Tablet · Dog 0.5–1 kg Dog 0.5–1 kg 1 tablet
One tablet for 0.5-1 kg (instruction table for the tablet for puppies and dogs up to 5 kg: 0.5-1 kg 1, 1-2.5 kg 1, 2.5-5 kg 2). A single dose with a little food at the morning feed; for prevention once a quarter and before vaccination or mating. Not with hypersensitivity, marked kidney or liver failure, in exhausted or infectious-sick animals, or under 0.5 kg or 2 weeks of age; Collies, Bobtails and Shelties only under veterinary supervision.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 5კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002533
Verified on: 15 Oct 2026
Tablet · Dog 1–2.5 kg Dog 1–2.5 kg 1 tablet
Give 1 tablet for a body weight of 1–2.5 kg, according to the instruction table.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 5კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002533
Verified on: 15 Oct 2026
Tablet · Dog 2.5–5 kg Dog 2.5–5 kg 2 tablets
Give 2 tablets for a body weight of 2.5–5 kg, according to the instruction table.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 5კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002533
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Supramil, Tablet

milbemycin oxime 1.25 mg + R-praziquantel 6.25 mg, tablet for dogs up to 5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
6.8/10
Situational / acceptable
vetman assessment

Supramil

milbemycin oxime 1.25 mg + R-praziquantel 6.25 mg, tablet for dogs up to 5 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible intestinal cestodes and nematodes and prevention of Dirofilaria immitis infection, with combined use only when both active components are justified · By mouth
Care settingWeight-band tablet used after accurate weighing, parasite and heartworm-risk assessment, and review of the exact current package instruction
vetman score 6.8/10 Situational / acceptable
Evidence confidence: Low Georgia: Expired · № 002533 · Verified on 15 Oct 2026

A practical broad anthelmintic with direct exact-brand field data, but no Georgian registration is currently in force and its evidence and regulatory transparency remain materially thinner than for mature internationally assessed alternatives.

Regulatory and scientific credibility5.5/10

The Georgian register snapshot lists the exact authorisations only through 15-20 October 2026, with no renewal verified as of assessment. The forms appear in the current Russian national instruction but lack an EMA/FDA/VMD-style public assessment dossier and broad international regulatory history.

Clinical efficacy7.5/10

A manufacturer-linked 2019 controlled field report directly studied the exact species presentations and reported complete clearance across susceptible intestinal helminths; the established milbemycin-combination literature is supportive, but independent peer-reviewed exact-brand evidence is limited.

Safety and tolerability6.5/10

The established active ingredients have a generally predictable safety profile at labelled doses, but exact-brand safety evidence is mainly limited to small short-term groups. Microfilaraemic animals can react, MDR1-sensitive dogs require strict dosing, and renal, hepatic, age and weight restrictions apply.

Clinical practicality8.0/10

Small flavoured weight-band tablets and single-dose intestinal-worm treatment are practical; accurate weighing, administration with food and parasite-specific monthly prevention or repeat schedules remain necessary.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use the fixed combination only when its cestode and nematode or heartworm-prevention components are jointly justified; avoid unnecessary exposure to either active substance.
  • Before heartworm prevention in an endemic area, establish infection and microfilariae status. Do not interpret the small 2019 microfilaricidal study as support for adulticide treatment of established heartworm disease.
  • Use caution with other macrocyclic lactones or P-glycoprotein substrates/inhibitors; susceptible animals may have a narrower safety margin.
  • Control intermediate hosts for Dipylidium and follow local zoonosis procedures for Echinococcus; an anthelmintic dose alone does not prevent reinfection.
  • Weigh accurately and observe the exact minimum age and weight restrictions. In Collies, related breeds or suspected MDR1 deficiency, never exceed the current label dose; avoid use in marked renal or hepatic dysfunction unless the verified label permits it.
Assessment sources
  1. Rosselkhoznadzor 20242024
  2. Supramil clinical report 20192019
  3. Milbemax Thelazia RCT2012
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Milbemycin oxime1.25 mg Arpraziquantel6.25 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Astrafarm · Russia
Registration
Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 5კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002533
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
This tablet is for dogs; no feline dose is provided in the instructions.
 Cat Any weight By mouth - Product label (SPC)
1 tablet
One tablet for 0.5-1 kg (instruction table for the tablet for puppies and dogs up to 5 kg: 0.5-1 kg 1, 1-2.5 kg 1, 2.5-5 kg 2). A single dose with a little food at the morning feed; for prevention once a quarter and before vaccination or mating. Not with hypersensitivity, marked kidney or liver failure, in exhausted or infectious-sick animals, or under 0.5 kg or 2 weeks of age; Collies, Bobtails and Shelties only under veterinary supervision.
 Dog 0.5–1 kg By mouth once Product label (SPC)
1 tablet
Give 1 tablet for a body weight of 1–2.5 kg, according to the instruction table.
 Dog 1–2.5 kg By mouth once Product label (SPC)
2 tablets
Give 2 tablets for a body weight of 2.5–5 kg, according to the instruction table.
 Dog 2.5–5 kg By mouth once Product label (SPC)
Tablet · Cat 0.5–1 kg Cat 0.5–1 kg 1 tablet
One tablet for 0.5-1 kg (instruction table for the tablet for kittens and cats up to 2 kg: 0.5-1 kg 1, 1-2 kg 2). A single dose at the morning feed. Not for kittens under 0.5 kg or 6 weeks of age.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-მდე კატებისა და კნუტებისთვის
№ 002534
Verified on: 15 Oct 2026
Tablet · Cat 1–2 kg Cat 1–2 kg 2 tablets
Give 2 tablets for a body weight of 1–2 kg, according to the instruction table.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-მდე კატებისა და კნუტებისთვის
№ 002534
Verified on: 15 Oct 2026
Tablet · Dog Any weight Dog Any weight No dose for this species
This tablet is for cats; no canine dose is provided in the instructions.
 - Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-მდე კატებისა და კნუტებისთვის
№ 002534
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Supramil, Tablet

milbemycin oxime 2 mg + R-praziquantel 2.5 mg, tablet for cats up to 2 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
6.8/10
Situational / acceptable
vetman assessment

Supramil

milbemycin oxime 2 mg + R-praziquantel 2.5 mg, tablet for cats up to 2 kg
Assessed clinical scopeCat · Full labelled species-specific scope for susceptible intestinal cestodes and nematodes and prevention of Dirofilaria immitis infection, with combined use only when both active components are justified · By mouth
Care settingWeight-band tablet used after accurate weighing, parasite and heartworm-risk assessment, and review of the exact current package instruction
vetman score 6.8/10 Situational / acceptable
Evidence confidence: Low Georgia: Expired · № 002534 · Verified on 15 Oct 2026

A practical broad anthelmintic with direct exact-brand field data, but no Georgian registration is currently in force and its evidence and regulatory transparency remain materially thinner than for mature internationally assessed alternatives.

Regulatory and scientific credibility5.5/10

The Georgian register snapshot lists the exact authorisations only through 15-20 October 2026, with no renewal verified as of assessment. The forms appear in the current Russian national instruction but lack an EMA/FDA/VMD-style public assessment dossier and broad international regulatory history.

Clinical efficacy7.5/10

A manufacturer-linked 2019 controlled field report directly studied the exact species presentations and reported complete clearance across susceptible intestinal helminths; the established milbemycin-combination literature is supportive, but independent peer-reviewed exact-brand evidence is limited.

Safety and tolerability6.5/10

The established active ingredients have a generally predictable safety profile at labelled doses, but exact-brand safety evidence is mainly limited to small short-term groups. Microfilaraemic animals can react, MDR1-sensitive dogs require strict dosing, and renal, hepatic, age and weight restrictions apply.

Clinical practicality8.0/10

Small flavoured weight-band tablets and single-dose intestinal-worm treatment are practical; accurate weighing, administration with food and parasite-specific monthly prevention or repeat schedules remain necessary.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use the fixed combination only when its cestode and nematode or heartworm-prevention components are jointly justified; avoid unnecessary exposure to either active substance.
  • Before heartworm prevention in an endemic area, establish infection and microfilariae status. Do not interpret the small 2019 microfilaricidal study as support for adulticide treatment of established heartworm disease.
  • Use caution with other macrocyclic lactones or P-glycoprotein substrates/inhibitors; susceptible animals may have a narrower safety margin.
  • Control intermediate hosts for Dipylidium and follow local zoonosis procedures for Echinococcus; an anthelmintic dose alone does not prevent reinfection.
  • Weigh accurately and use only the matching feline tablet. Observe the exact minimum age and weight restrictions, and avoid use in marked renal or hepatic dysfunction unless the verified label permits it.
Assessment sources
  1. Rosselkhoznadzor 20242024
  2. Supramil clinical report 20192019
  3. Milbemax Thelazia RCT2012
  4. Milbemax Toxocara cat study2007
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Milbemycin oxime2 mg Arpraziquantel2.5 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Astrafarm · Russia
Registration
Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-მდე კატებისა და კნუტებისთვის
№ 002534
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 tablet
One tablet for 0.5-1 kg (instruction table for the tablet for kittens and cats up to 2 kg: 0.5-1 kg 1, 1-2 kg 2). A single dose at the morning feed. Not for kittens under 0.5 kg or 6 weeks of age.
 Cat 0.5–1 kg By mouth once Product label (SPC)
2 tablets
Give 2 tablets for a body weight of 1–2 kg, according to the instruction table.
 Cat 1–2 kg By mouth once Product label (SPC)
No dose for this species
This tablet is for cats; no canine dose is provided in the instructions.
 Dog Any weight By mouth - Product label (SPC)
Tablet · Cat Any weight Cat Any weight No dose for this species
This tablet is for dogs; no feline dose is provided in the instructions.
 - Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები“ 20კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002532
Verified on: 15 Oct 2026
Tablet · Dog 5–10 kg Dog 5–10 kg 1 tablet
One tablet for 5-10 kg (instruction table for the tablet for puppies and dogs up to 20 kg: 5-10 kg 1, 10-20 kg 2, 20-25 kg 3). A single dose at the morning feed. Heartworm prevention: monthly through the mosquito season, the last dose 1 month after it ends; rule out microfilariae first.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები“ 20კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002532
Verified on: 15 Oct 2026
Tablet · Dog 10–20 kg Dog 10–20 kg 2 tablets
Give 2 tablets for a body weight of 10–20 kg, according to the instruction table.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები“ 20კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002532
Verified on: 15 Oct 2026
Tablet · Dog 20–25 kg Dog 20–25 kg 3 tablets
Give 3 tablets for a body weight of 20–25 kg, according to the instruction table.
 · once		 once Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები“ 20კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002532
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Supramil, Tablet

milbemycin oxime 5 mg + R-praziquantel 25 mg, tablet for dogs up to 20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
6.8/10
Situational / acceptable
vetman assessment

Supramil

milbemycin oxime 5 mg + R-praziquantel 25 mg, tablet for dogs up to 20 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible intestinal cestodes and nematodes and prevention of Dirofilaria immitis infection, with combined use only when both active components are justified · By mouth
Care settingWeight-band tablet used after accurate weighing, parasite and heartworm-risk assessment, and review of the exact current package instruction
vetman score 6.8/10 Situational / acceptable
Evidence confidence: Low Georgia: Expired · № 002532 · Verified on 15 Oct 2026

A practical broad anthelmintic with direct exact-brand field data, but no Georgian registration is currently in force and its evidence and regulatory transparency remain materially thinner than for mature internationally assessed alternatives.

Regulatory and scientific credibility5.5/10

The Georgian register snapshot lists the exact authorisations only through 15-20 October 2026, with no renewal verified as of assessment. The forms appear in the current Russian national instruction but lack an EMA/FDA/VMD-style public assessment dossier and broad international regulatory history.

Clinical efficacy7.5/10

A manufacturer-linked 2019 controlled field report directly studied the exact species presentations and reported complete clearance across susceptible intestinal helminths; the established milbemycin-combination literature is supportive, but independent peer-reviewed exact-brand evidence is limited.

Safety and tolerability6.5/10

The established active ingredients have a generally predictable safety profile at labelled doses, but exact-brand safety evidence is mainly limited to small short-term groups. Microfilaraemic animals can react, MDR1-sensitive dogs require strict dosing, and renal, hepatic, age and weight restrictions apply.

Clinical practicality8.0/10

Small flavoured weight-band tablets and single-dose intestinal-worm treatment are practical; accurate weighing, administration with food and parasite-specific monthly prevention or repeat schedules remain necessary.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use the fixed combination only when its cestode and nematode or heartworm-prevention components are jointly justified; avoid unnecessary exposure to either active substance.
  • Before heartworm prevention in an endemic area, establish infection and microfilariae status. Do not interpret the small 2019 microfilaricidal study as support for adulticide treatment of established heartworm disease.
  • Use caution with other macrocyclic lactones or P-glycoprotein substrates/inhibitors; susceptible animals may have a narrower safety margin.
  • Control intermediate hosts for Dipylidium and follow local zoonosis procedures for Echinococcus; an anthelmintic dose alone does not prevent reinfection.
  • Weigh accurately and observe the exact minimum age and weight restrictions. In Collies, related breeds or suspected MDR1 deficiency, never exceed the current label dose; avoid use in marked renal or hepatic dysfunction unless the verified label permits it.
Assessment sources
  1. Rosselkhoznadzor 20242024
  2. Supramil clinical report 20192019
  3. Milbemax Thelazia RCT2012
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Milbemycin oxime5 mg Arpraziquantel25 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Astrafarm · Russia
Registration
Georgia Expired
Expired on 15 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები“ 20კგ-მდე ლეკვებისა და ძაღლებისათვის
№ 002532
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
This tablet is for dogs; no feline dose is provided in the instructions.
 Cat Any weight By mouth - Product label (SPC)
1 tablet
One tablet for 5-10 kg (instruction table for the tablet for puppies and dogs up to 20 kg: 5-10 kg 1, 10-20 kg 2, 20-25 kg 3). A single dose at the morning feed. Heartworm prevention: monthly through the mosquito season, the last dose 1 month after it ends; rule out microfilariae first.
 Dog 5–10 kg By mouth once Product label (SPC)
2 tablets
Give 2 tablets for a body weight of 10–20 kg, according to the instruction table.
 Dog 10–20 kg By mouth once Product label (SPC)
3 tablets
Give 3 tablets for a body weight of 20–25 kg, according to the instruction table.
 Dog 20–25 kg By mouth once Product label (SPC)
Tablet · Cat 2–4 kg Cat 2–4 kg 1 tablet
One tablet for 2-4 kg (instruction table for the tablet for cats from 2 kg: 2-4 kg 1, 4-8 kg 2). A single dose at the morning feed; for prevention once a quarter.
 · once		 once Georgia Expired
Expired on 20 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-დან კატებისთვის
№ 002536
Verified on: 15 Oct 2026
Tablet · Cat 4–8 kg Cat 4–8 kg 2 tablets
Give 2 tablets for a body weight of 4–8 kg, according to the instruction table.
 · once		 once Georgia Expired
Expired on 20 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-დან კატებისთვის
№ 002536
Verified on: 15 Oct 2026
Tablet · Dog Any weight Dog Any weight No dose for this species
This tablet is for cats; no canine dose is provided in the instructions.
 - Georgia Expired
Expired on 20 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-დან კატებისთვის
№ 002536
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Supramil, Tablet

milbemycin oxime 8 mg + R-praziquantel 10 mg, tablet for cats from 2 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
6.8/10
Situational / acceptable
vetman assessment

Supramil

milbemycin oxime 8 mg + R-praziquantel 10 mg, tablet for cats from 2 kg
Assessed clinical scopeCat · Full labelled species-specific scope for susceptible intestinal cestodes and nematodes and prevention of Dirofilaria immitis infection, with combined use only when both active components are justified · By mouth
Care settingWeight-band tablet used after accurate weighing, parasite and heartworm-risk assessment, and review of the exact current package instruction
vetman score 6.8/10 Situational / acceptable
Evidence confidence: Low Georgia: Expired · № 002536 · Verified on 15 Oct 2026

A practical broad anthelmintic with direct exact-brand field data, but no Georgian registration is currently in force and its evidence and regulatory transparency remain materially thinner than for mature internationally assessed alternatives.

Regulatory and scientific credibility5.5/10

The Georgian register snapshot lists the exact authorisations only through 15-20 October 2026, with no renewal verified as of assessment. The forms appear in the current Russian national instruction but lack an EMA/FDA/VMD-style public assessment dossier and broad international regulatory history.

Clinical efficacy7.5/10

A manufacturer-linked 2019 controlled field report directly studied the exact species presentations and reported complete clearance across susceptible intestinal helminths; the established milbemycin-combination literature is supportive, but independent peer-reviewed exact-brand evidence is limited.

Safety and tolerability6.5/10

The established active ingredients have a generally predictable safety profile at labelled doses, but exact-brand safety evidence is mainly limited to small short-term groups. Microfilaraemic animals can react, MDR1-sensitive dogs require strict dosing, and renal, hepatic, age and weight restrictions apply.

Clinical practicality8.0/10

Small flavoured weight-band tablets and single-dose intestinal-worm treatment are practical; accurate weighing, administration with food and parasite-specific monthly prevention or repeat schedules remain necessary.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use the fixed combination only when its cestode and nematode or heartworm-prevention components are jointly justified; avoid unnecessary exposure to either active substance.
  • Before heartworm prevention in an endemic area, establish infection and microfilariae status. Do not interpret the small 2019 microfilaricidal study as support for adulticide treatment of established heartworm disease.
  • Use caution with other macrocyclic lactones or P-glycoprotein substrates/inhibitors; susceptible animals may have a narrower safety margin.
  • Control intermediate hosts for Dipylidium and follow local zoonosis procedures for Echinococcus; an anthelmintic dose alone does not prevent reinfection.
  • Weigh accurately and use only the matching feline tablet. Observe the exact minimum age and weight restrictions, and avoid use in marked renal or hepatic dysfunction unless the verified label permits it.
Assessment sources
  1. Rosselkhoznadzor 20242024
  2. Supramil clinical report 20192019
  3. Milbemax Thelazia RCT2012
  4. Milbemax Toxocara cat study2007
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Milbemycin oxime8 mg Arpraziquantel10 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Astrafarm · Russia
Manufacturer (register)
Scientific Innovative Enterprise Astrafarm Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 485, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Expired
Expired on 20 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 2კგ-დან კატებისთვის
№ 002536
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 tablet
One tablet for 2-4 kg (instruction table for the tablet for cats from 2 kg: 2-4 kg 1, 4-8 kg 2). A single dose at the morning feed; for prevention once a quarter.
 Cat 2–4 kg By mouth once Product label (SPC)
2 tablets
Give 2 tablets for a body weight of 4–8 kg, according to the instruction table.
 Cat 4–8 kg By mouth once Product label (SPC)
No dose for this species
This tablet is for cats; no canine dose is provided in the instructions.
 Dog Any weight By mouth - Product label (SPC)
Tablet - - No label dose in the reference yet - Georgia Expired
Expired on 19 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 20კგ-დან 50კგ-მდე ძაღლებისთვის
№ 002535
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Supramil, Tablet

milbemycin oxime 12.5 mg + R-praziquantel 62.5 mg, tablet for dogs 20-50 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
6.1/10
Situational / acceptable
vetman assessment

Supramil

milbemycin oxime 12.5 mg + R-praziquantel 62.5 mg, tablet for dogs 20-50 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible intestinal cestodes and nematodes and prevention of Dirofilaria immitis infection, with combined use only when both active components are justified · By mouth
Care settingWeight-band tablet used after accurate weighing, parasite and heartworm-risk assessment, and review of the exact current package instruction
vetman score 6.1/10 Situational / acceptable
Evidence confidence: Low Georgia: Expired · № 002535 · Verified on 15 Oct 2026

Direct but limited exact-form evidence prevents dismissal, yet both the expired Georgian certificate and the current-label mismatch materially weaken confidence; use only after confirming the current pack, dose table and legal status.

Regulatory and scientific credibility4.5/10

The Georgian register snapshot lists authorisation 002535 only through 19 October 2026, and no renewal has been verified as of assessment. The form was directly studied in 2019 but is absent from the current 2024 Russian national instruction, which now lists only four other presentations.

Clinical efficacy6.5/10

A manufacturer-linked 2019 controlled field report directly studied this strength and reported complete clearance in small groups, including microfilariae; however, it is not peer reviewed, sample sizes were small and the current national label no longer lists this presentation.

Safety and tolerability6.5/10

The established active ingredients have a generally predictable safety profile at labelled doses, but exact-brand safety evidence is mainly limited to small short-term groups. Microfilaraemic animals can react, MDR1-sensitive dogs require strict dosing, and renal, hepatic, age and weight restrictions apply.

Clinical practicality7.5/10

The large-dog tablet is convenient in principle, but the discrepancy between the registered presentation, the 2019 study and the current national instruction makes the current package dosing table essential before use.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use the fixed combination only when its cestode and nematode or heartworm-prevention components are jointly justified; avoid unnecessary exposure to either active substance.
  • Before heartworm prevention in an endemic area, establish infection and microfilariae status. Do not interpret the small 2019 microfilaricidal study as support for adulticide treatment of established heartworm disease.
  • Use caution with other macrocyclic lactones or P-glycoprotein substrates/inhibitors; susceptible animals may have a narrower safety margin.
  • Control intermediate hosts for Dipylidium and follow local zoonosis procedures for Echinococcus; an anthelmintic dose alone does not prevent reinfection.
  • This 12.5/62.5 mg presentation has an expired Georgian certificate and appears in the 2019 exact-brand report, but not in the current 2024 Russian national instruction. Confirm the physical pack, current leaflet, dose table and legal authorisation before prescribing.
Assessment sources
  1. Rosselkhoznadzor 20242024
  2. Supramil clinical report 20192019
  3. Milbemax Thelazia RCT2012
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Milbemycin oxime12.5 mg Arpraziquantel62.5 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Astrafarm · Russia
Manufacturer (register)
Scientific Innovative Enterprise Astrafarm Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 484, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Expired
Expired on 19 Oct 2026, not renewed yet
Veterinary (National Food Agency)
In the register: სუპრამილი® ტაბლეტები - 20კგ-დან 50კგ-მდე ძაღლებისთვის
№ 002535
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Active substance doses, with sources
Active substance Milbemycin oxime
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
0.5 mg/kg Dog Maintenance By mouth once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Milpro 2.5 mg/25 mg film-coated tablets for small dogs and puppies - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
2 mg/kg Cat Maintenance By mouth once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Milpro 4 mg/10 mg film-coated tablets for small cats and kittens - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Arpraziquantel: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Milbemycin oxime
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Milbemycin oxime
    Severe kidney impairment: one product label lists marked kidney or liver dysfunction as a contraindication. Another notes that no studies exist in severely debilitated dogs or in animals with seriously impaired kidney or liver function, and does not recommend use in them, or only after a benefit-risk assessment.
    Sources: VMD SPC · VMD
  • Critical Milbemycin oxime
    Severe liver impairment: one product label lists marked kidney or liver dysfunction as a contraindication. Another does not recommend use in animals with seriously impaired kidney or liver function, or only after a benefit-risk assessment.
    Sources: VMD SPC · VMD
  • Critical Milbemycin oxime (Dog)
    Do not use in puppies of less than 2 weeks of age and/or weighing less than 0.5 kg.
    Sources: VMD SPC · VMD
  • Critical Milbemycin oxime (Cat)
    Do not use in kittens of less than 6 weeks of age and/or weighing less than 0.5 kg.
    Sources: VMD SPC · VMD
  • Warning Milbemycin oxime
    Emaciated, severely debilitated animals and animals with an infectious disease: one product label excludes them from deworming; another does not recommend use in severely debilitated animals, or only after a benefit-risk assessment.
    Sources: VMD SPC · VMD
  • Warning Milbemycin oxime (Dog)
    the margin of safety in certain dogs of Collie or related breeds is less than in other breeds. In these dogs, the recommended dose should be strictly observed. The tolerance of the veterinary medicinal product in young puppies from these breeds has not been investigated.
    Sources: VMD SPC · VMD
  • Warning Milbemycin oxime (Dog)
    The use in dogs suffering from microfilaremia is thus not recommended. In the case of a positive diagnosis, adulticidal therapy is indicated before administering the veterinary medicinal product.
    Sources: VMD SPC · VMD
  • Caution Milbemycin oxime
    In a study, this combination of active substances was demonstrated to be well tolerated in breeding bitches, including during pregnancy and lactation. As a specific study with this veterinary medicinal product has not been performed, use during pregnancy and lactation only according to the benefit-risk assessment
    Sources: VMD SPC · VMD
  • Caution Milbemycin oxime
    use during pregnancy and lactation only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Caution Milbemycin oxime (Cat)
    In the absence of data on cats with microfilaraemia, its use should be according to a benefit risk assessment by the attending veterinarian.
    Sources: VMD SPC · VMD
  • Known Breed Sensitivities Milbemycin oxime
    Collie, Collie (unspecified), Collie - Scottish Rough, Collie - Scottish Smooth, Sheepdog - Old English, Sheepdog - Shetland (Sheltie), Shetland Sheepdog
    the margin of safety in certain dogs of Collie or related breeds is less than in other breeds. In these dogs, the recommended dose should be strictly observed.

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

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