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Rex and Musya

Fipronil · O.L.KAR-AgroZoovet-Service

2 forms: aerosol / spray, spot-on. In force in Georgia: 2 of 2 (veterinary register).

Forms and doses2 of 2 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Aerosol / spray · Cat Any weight Cat Any weight Ectoparasite Infestation · On the skin: 2–5 ml/kgEctoparasite Infestation · Into the ear: 0.5 ml - Georgia Yes, veterinary
In force until 06 Nov 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული სპრეი ძაღლებისა და კატებისთვის
№ 000490
Verified on: 21 Oct 2026
Aerosol / spray · Dog Any weight Dog Any weight Ectoparasite Infestation · On the skin: 2–5 ml/kgEctoparasite Infestation · Into the ear: 0.5 ml - Georgia Yes, veterinary
In force until 06 Nov 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული სპრეი ძაღლებისა და კატებისთვის
№ 000490
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Rex and Musya, Aerosol / spray

fipronil 3 mg/ml cutaneous spray, 150 ml for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label from 10 weeks and 1 kg: flea, tick, louse, biting-louse and mange mite treatment with a fipronil 0.3% spray on the coat, plus ear-mite treatment by ear
5.8/10
Weak evidence support
vetman assessment

Rex and Musya

fipronil 3 mg/ml cutaneous spray, 150 ml for dogs and cats
Assessed clinical scopeDog · Full dog label from 10 weeks and 1 kg: flea, tick, louse, biting-louse and mange mite treatment with a fipronil 0.3% spray on the coat, plus ear-mite treatment by ear · topical,otic
Care settingClinic or owner spray treatment outdoors or in a ventilated area; ear use after veterinary confirmation of ear mites
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000490 · Verified on 21 Oct 2026

A weak option: the fipronil dose matches proven sprays, but extra mange and ear claims are unsupported and the exact product has no independent evidence.

Regulatory and scientific credibility5.0/10

The exact 150 ml spray is registered in Georgia (000490, valid to 2028) with a current Ukrainian manufacturer instruction; fipronil sprays are EU-authorised, but this product has no EU, UK or US dossier.

Clinical efficacy6.0/10

At 2-5 ml/kg the dog receives 6-15 mg/kg fipronil, close to proven fipronil sprays; the mange and ear-mite claims rest only on manufacturer material.

Safety and tolerability6.5/10

Fipronil is well tolerated by dogs; the label excludes sick dogs, pregnancy, lactation, puppies under 10 weeks and dogs below 1 kg, and spraying into the ear is an unusual route.

Clinical practicality5.5/10

Wetting the whole coat at 2-5 ml/kg needs a ventilated area, 48 hours without bathing or petting, and 2-3 repeats for mange or lice.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in sick or debilitated dogs, during pregnancy or lactation, in puppies under 10 weeks or dogs below 1 kg.
  • Never use on rabbits: fipronil is toxic to them.
  • Before spraying into the ear, check that the eardrum is intact; clean the canal and treat both ears.
  • For sarcoptic mange or demodicosis, prefer a systemic isoxazoline with proven efficacy.
  • Do not bathe or pet for 48 hours; keep the dog in a ventilated area until dry.
Assessment sources
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full cat label from 10 weeks: flea, tick, louse, biting-louse and mange mite treatment with a fipronil 0.3% spray on the coat, plus ear-mite treatment by ear
5.7/10
Weak evidence support
vetman assessment

Rex and Musya

fipronil 3 mg/ml cutaneous spray, 150 ml for dogs and cats
Assessed clinical scopeCat · Full cat label from 10 weeks: flea, tick, louse, biting-louse and mange mite treatment with a fipronil 0.3% spray on the coat, plus ear-mite treatment by ear · topical,otic
Care settingClinic or owner spray treatment in a ventilated area with licking prevented; ear use after veterinary confirmation of ear mites
vetman score 5.7/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000490 · Verified on 21 Oct 2026

A weak option for cats: a correctly dosed fipronil spray, but hard to apply and without independent product evidence for its wider claims.

Regulatory and scientific credibility5.0/10

The exact 150 ml spray is registered in Georgia for cats and dogs (000490, valid to 2028) with a current Ukrainian manufacturer instruction, but it has no EU, UK or US dossier.

Clinical efficacy6.0/10

At 2-5 ml/kg the cat receives 6-15 mg/kg fipronil, close to proven fipronil sprays; the mange and ear-mite claims rest only on manufacturer material.

Safety and tolerability6.5/10

Fipronil is safe in cats, but grooming a wet coat raises oral exposure; the label excludes sick cats, pregnancy, lactation and kittens under 10 weeks.

Clinical practicality5.0/10

Spraying a cat to the skin and keeping it in a ventilated area until dry is difficult, and 48 hours without bathing or petting are required.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in sick or debilitated cats, during pregnancy or lactation, or in kittens under 10 weeks.
  • Never use on rabbits: fipronil is toxic to them.
  • Prevent licking until dry; hypersalivation can follow if the cat licks the wet coat.
  • Before spraying into the ear, check that the eardrum is intact; clean the canal and treat both ears.
  • Do not bathe or pet for 48 hours.
Assessment sources
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil3 mg/ml
Formulation Type
Aerosol / spray
Administration route
On the skin, Into the ear
Manufacturer
Manufacturer (register)
O.L.KAR-Agrozoovet-service, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 940, 19 Oct 2026.
Registration
Georgia Yes, veterinary
In force until 06 Nov 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული სპრეი ძაღლებისა და კატებისთვის
№ 000490
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Cat
WeightEctoparasite Infestation · On the skinEctoparasite Infestation · Into the ear
Any weight 2–5 ml/kg 0.5 ml
  • Ectoparasite Infestation · On the skin (2-3 treatments, 10-12 days apart when treating mange, lice or biting lice): Shake the bottle and spray the entire pre-ruffled coat from 10-15 cm against hair growth until the product reaches the skin. Five actuator presses deliver 0.5 ml. Use outdoors or in a well-ventilated area and keep the animal there until dry. A tick attached to the skin may be treated directly with 0.5 ml. Do not use in sick or debilitated animals, during pregnancy or lactation, in kittens under 10 weeks, or with component hypersensitivity. Prevent ingestion and licking. Do not bathe or pet for 48 hours.
  • Ectoparasite Infestation · Into the ear (single otic treatment): Clean the pinna and ear canal, then spray 0.5 ml into EACH ear. Fold and gently massage the ear base, holding the head for 5-10 minutes. Treat both ears even when only one appears affected. Apply the same restrictions as for cutaneous treatment.
Source:
O.L.KAR Rex and Musya spray
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya spray - current official product instruction
O.L.KAR official veterinary product instruction
Dog
WeightEctoparasite Infestation · On the skinEctoparasite Infestation · Into the ear
Any weight 2–5 ml/kg 0.5 ml
  • Ectoparasite Infestation · On the skin (2-3 treatments, 10-12 days apart when treating mange, lice or biting lice): Shake the bottle and spray the entire pre-ruffled coat from 10-15 cm against hair growth until the product reaches the skin. Five actuator presses deliver 0.5 ml. Use outdoors or in a well-ventilated area and keep the animal there until dry. A tick attached to the skin may be treated directly with 0.5 ml. Do not use in sick or debilitated animals, during pregnancy or lactation, in puppies under 10 weeks or dogs below 1 kg, or with component hypersensitivity. Prevent ingestion and licking. Do not bathe or pet for 48 hours.
  • Ectoparasite Infestation · Into the ear (single otic treatment): Clean the pinna and ear canal, then spray 0.5 ml into EACH ear. Fold and gently massage the ear base, holding the head for 5-10 minutes. Treat both ears even when only one appears affected. Apply the same restrictions as for cutaneous treatment.
Source:
O.L.KAR Rex and Musya spray
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya spray - current official product instruction
O.L.KAR official veterinary product instruction
Spot-on · Cat up to 1 kg Cat up to 1 kg 10 drops
Cut the dropper tip and apply once to dry, intact skin where licking is impossible. For mange, lice or biting lice, apply 2-3 times at 10-12 day intervals. Repeat against ixodid ticks no more than monthly and against insects no more than every two months. Do not use under 10 weeks, during pregnancy or lactation, with infectious disease or fipronil hypersensitivity. Do not bathe or pet the treated skin for 48 hours.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Cat Any weight Cat Any weight 4–6 drops
For label treatment of otodectosis: clean the pinna and external ear canal, instil 4-6 drops into each ear even when only one ear is affected, then fold and gently massage the ear base. Confirm the diagnosis and tympanic membrane integrity before use. Apply the remainder on the back as directed by the label.
· repeat only after veterinary reassessment according to the official instruction
repeat only after veterinary reassessment according to the official instruction Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Cat 1–3 kg Cat 1–3 kg 12–20 drops
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Cat over 3 kg Cat over 3 kg 1.5 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Dog Any weight Dog Any weight 4–6 drops
For label treatment of otodectosis: clean the pinna and external ear canal, instil 4-6 drops into each ear even when only one ear is affected, then fold and gently massage the ear base. Confirm the diagnosis and tympanic membrane integrity before use. Apply the remainder on the back as directed by the label.
· repeat only after veterinary reassessment according to the official instruction
repeat only after veterinary reassessment according to the official instruction Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Dog 1–10 kg Dog 1–10 kg 0.5–1 ml
Cut the dropper tip and apply once to dry, intact skin where licking is impossible. For dogs over 50 kg, the label says to add 1 ml for each subsequent 10 kg; that open-ended step is not extrapolated by the calculator. For mange, lice or biting lice, apply 2-3 times at 10-12 day intervals. Repeat against ixodid ticks no more than monthly and against insects no more than every two months. Do not use under 10 weeks, during pregnancy or lactation, with infectious disease or fipronil hypersensitivity. Do not bathe or pet the treated skin for 48 hours.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Dog 10–20 kg Dog 10–20 kg 1.2–2 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction. For dogs over 50 kg, the label says to add 1 ml for each subsequent 10 kg; the calculator does not extrapolate that open-ended step.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Dog 20–30 kg Dog 20–30 kg 2.3–3 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction. For dogs over 50 kg, the calculator does not extrapolate the label's open-ended 1 ml per subsequent 10 kg step.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Spot-on · Dog 30–50 kg Dog 30–50 kg 3.4–4 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction. For dogs over 50 kg, the calculator does not extrapolate the label's open-ended 1 ml per subsequent 10 kg step.
· once; repeat only as directed by the label
once; repeat only as directed by the label Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Rex and Musya, Spot-on

fipronil 80 mg/ml spot-on solution, 4 x 1 ml for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal
4.6/10
Weak evidence support
vetman assessment

Rex and Musya

fipronil 80 mg/ml spot-on solution, 4 x 1 ml for dogs and cats
Assessed clinical scopeDog · Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal · auricular
Care settingVeterinary diagnosis after otoscopy and microscopy; clean the external canal, verify tympanic membrane integrity and reassess before repetition.
vetman score 4.6/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000466 · Verified on 21 Oct 2026

A weak, low-confidence label-supported otic option: the regimen is stated, but exact-formulation efficacy and ototoxicity evidence are absent. Prefer a product with regulator-reviewed otic data and always confirm an intact tympanum.

Regulatory and scientific credibility4.5/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The instruction is product-specific, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found; several dose bands are ranges rather than fixed pipette units.

Clinical efficacy4.0/10

The exact instruction provides an otic regimen, but no exact-product controlled auricular efficacy study was found. Evidence for fipronil spot-on control of fleas and ticks is not direct evidence for this solvent, concentration and repeated ear-canal regimen.

Safety and tolerability4.0/10

Exact-formulation ear-canal safety and ototoxicity data were not found. Use only after confirming an intact tympanic membrane; stop for pain, neurologic signs, marked irritation or hearing change. Class safety from dermal spot-on use cannot be assumed to prove otic safety.

Clinical practicality6.5/10

The 4-6 drops per ear regimen is measurable and the remaining ampoule is applied to the back, but canal cleaning, bilateral dosing, massage, restraint and reassessment are required. The single-use 1 ml ampoule limits storage ambiguity.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Confirm otodectosis by otoscopy/microscopy and verify an intact tympanic membrane before use. Do not apply into a perforated, unvisualised, severely inflamed or neurologically abnormal ear.
  • Clean both external canals, treat both ears even with unilateral signs and massage the ear base as directed. Stop and reassess for pain, head tilt, nystagmus, ataxia, hearing change or marked irritation.
  • Spot-on flea/tick efficacy and dermal safety studies do not establish efficacy or ototoxicity safety for this exact repeated ear-canal regimen. Evidence confidence is low.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Dog Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them
4.8/10
Weak evidence support
vetman assessment

Rex and Musya

fipronil 80 mg/ml spot-on solution, 4 x 1 ml for dogs and cats
Assessed clinical scopeDog · Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them · On the skin
Care settingHome topical administration after veterinary selection of parasite target, weight band and retreatment interval; environmental control and household coverage as clinically indicated.
vetman score 4.8/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000466 · Verified on 21 Oct 2026

A weak exact-presentation option: fipronil class efficacy is credible, but dose design, broad claims or formulation-specific evidence are less convincing than current regulator-reviewed comparators. Use only within the exact label and reassess control rather than assuming class equivalence.

Regulatory and scientific credibility4.5/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The instruction is product-specific, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found; several dose bands are ranges rather than fixed pipette units.

Clinical efficacy5.0/10

Fipronil has applicable dog/cat spot-on evidence, but the exact product has no independent outcome study. Broad itch-mite and flea-allergic-dermatitis claims, variable dose ranges and product-specific persistence are supported mainly by the manufacturer instruction.

Safety and tolerability4.5/10

The label excludes animals under 10 weeks, dogs under 1 kg, pregnancy/lactation, illness and hypersensitivity, and restricts bathing/handling for 48 hours. Exact-formulation safety is not independently characterised, while wide topical ranges and a 1.5 ml feline dose increase dose-control uncertainty.

Clinical practicality5.5/10

One-millilitre ampoules are easy to open, but several bands are ranges, cats may require counting 10-20 drops or 1.5 ampoules, and larger dogs require multiple ampoules. A clear routine retreatment schedule is not stated in the structured label rows.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only on dry, intact skin in an area the animal cannot lick. Weigh the patient, select the exact label band and do not extrapolate between products, concentrations or pipette sizes.
  • Fipronil does not reliably prevent tick attachment or pathogen transmission. Examine the patient after exposure and use an integrated parasite plan based on local epidemiology and lifestyle.
  • The exact product has no independent controlled outcome trial or public regulator assessment dossier. Class evidence supports fipronil, not every broader mite, repellent or persistence claim on this formulation.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal
4.6/10
Weak evidence support
vetman assessment

Rex and Musya

fipronil 80 mg/ml spot-on solution, 4 x 1 ml for dogs and cats
Assessed clinical scopeCat · Label-concordant adjunctive treatment of Otodectes cynotis infestation in the external ear canal · auricular
Care settingVeterinary diagnosis after otoscopy and microscopy; clean the external canal, verify tympanic membrane integrity and reassess before repetition.
vetman score 4.6/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000466 · Verified on 21 Oct 2026

A weak, low-confidence label-supported otic option: the regimen is stated, but exact-formulation efficacy and ototoxicity evidence are absent. Prefer a product with regulator-reviewed otic data and always confirm an intact tympanum.

Regulatory and scientific credibility4.5/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The instruction is product-specific, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found; several dose bands are ranges rather than fixed pipette units.

Clinical efficacy4.0/10

The exact instruction provides an otic regimen, but no exact-product controlled auricular efficacy study was found. Evidence for fipronil spot-on control of fleas and ticks is not direct evidence for this solvent, concentration and repeated ear-canal regimen.

Safety and tolerability4.0/10

Exact-formulation ear-canal safety and ototoxicity data were not found. Use only after confirming an intact tympanic membrane; stop for pain, neurologic signs, marked irritation or hearing change. Class safety from dermal spot-on use cannot be assumed to prove otic safety.

Clinical practicality6.5/10

The 4-6 drops per ear regimen is measurable and the remaining ampoule is applied to the back, but canal cleaning, bilateral dosing, massage, restraint and reassessment are required. The single-use 1 ml ampoule limits storage ambiguity.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Confirm otodectosis by otoscopy/microscopy and verify an intact tympanic membrane before use. Do not apply into a perforated, unvisualised, severely inflamed or neurologically abnormal ear.
  • Clean both external canals, treat both ears even with unilateral signs and massage the ear base as directed. Stop and reassess for pain, head tilt, nystagmus, ataxia, hearing change or marked irritation.
  • Spot-on flea/tick efficacy and dermal safety studies do not establish efficacy or ototoxicity safety for this exact repeated ear-canal regimen. Evidence confidence is low.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them
4.7/10
Weak evidence support
vetman assessment

Rex and Musya

fipronil 80 mg/ml spot-on solution, 4 x 1 ml for dogs and cats
Assessed clinical scopeCat · Label-concordant treatment and prevention of susceptible flea, tick and louse infestations; broader mite or repellent claims are included only where the exact instruction states them · On the skin
Care settingHome topical administration after veterinary selection of parasite target, weight band and retreatment interval; environmental control and household coverage as clinically indicated.
vetman score 4.7/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 000466 · Verified on 21 Oct 2026

A weak exact-presentation option: fipronil class efficacy is credible, but dose design, broad claims or formulation-specific evidence are less convincing than current regulator-reviewed comparators. Use only within the exact label and reassess control rather than assuming class equivalence.

Regulatory and scientific credibility4.5/10

The exact presentation is actively registered in Georgia and has a current official manufacturer instruction. The instruction is product-specific, but no regulator-hosted public assessment dossier or independent exact-formulation trial was found; several dose bands are ranges rather than fixed pipette units.

Clinical efficacy5.0/10

Fipronil has applicable dog/cat spot-on evidence, but the exact product has no independent outcome study. Broad itch-mite and flea-allergic-dermatitis claims, variable dose ranges and product-specific persistence are supported mainly by the manufacturer instruction.

Safety and tolerability4.0/10

The label excludes animals under 10 weeks, dogs under 1 kg, pregnancy/lactation, illness and hypersensitivity, and restricts bathing/handling for 48 hours. Exact-formulation safety is not independently characterised, while wide topical ranges and a 1.5 ml feline dose increase dose-control uncertainty.

Clinical practicality5.5/10

One-millilitre ampoules are easy to open, but several bands are ranges, cats may require counting 10-20 drops or 1.5 ampoules, and larger dogs require multiple ampoules. A clear routine retreatment schedule is not stated in the structured label rows.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only on dry, intact skin in an area the animal cannot lick. Weigh the patient, select the exact label band and do not extrapolate between products, concentrations or pipette sizes.
  • Fipronil does not reliably prevent tick attachment or pathogen transmission. Examine the patient after exposure and use an integrated parasite plan based on local epidemiology and lifestyle.
  • The exact product has no independent controlled outcome trial or public regulator assessment dossier. Class evidence supports fipronil, not every broader mite, repellent or persistence claim on this formulation.
  • Respect every product-specific minimum age and weight. Do not transfer the eight-week/weight thresholds, pipette volumes or overdose margins of an authorised comparator to this presentation.
  • The exact instruction excludes pregnancy and lactation. Record reproductive status and choose another product for pregnant, breeding or nursing animals.
  • Do not use in sick, convalescent, exhausted or debilitated animals where the exact label excludes them. Avoid use in a patient with known fipronil or excipient hypersensitivity.
  • Prevent oral exposure and mutual grooming until the application site is dry. Brief hypersalivation can follow licking; vomiting, depression, tremor, marked salivation or other neurologic signs require prompt veterinary assessment.
  • Do not combine with another directly applied ectoparasiticide unless the compatibility and interval are explicitly established. Follow the exact bathing, handling and retreatment restrictions rather than shortening the interval after apparent failure.
  • Fipronil is hazardous to aquatic organisms. Keep treated animals away from water during the label restriction, prevent contamination of ponds and waterways, and dispose of pipettes and residue through the appropriate medicine-waste route.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil80 mg/ml Fipronil80 mg/ml
Formulation Type
Spot-on
Administration route
On the skin, auricular
Manufacturer
Manufacturer (register)
Private Enterprise O.L.KAR-AgroZoovet-Service, Ukraine
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 921, 19 Oct 2026.
Registration
Georgia Yes, veterinary
In force until 20 Oct 2028
Veterinary (National Food Agency)
In the register: რექსი და მუსია - ინსექტო-აკარიციდული წვეთები ძაღლებისა და კატებისთვის
№ 000466
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
10 drops
Cut the dropper tip and apply once to dry, intact skin where licking is impossible. For mange, lice or biting lice, apply 2-3 times at 10-12 day intervals. Repeat against ixodid ticks no more than monthly and against insects no more than every two months. Do not use under 10 weeks, during pregnancy or lactation, with infectious disease or fipronil hypersensitivity. Do not bathe or pet the treated skin for 48 hours.
Cat up to 1 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
4–6 drops
For label treatment of otodectosis: clean the pinna and external ear canal, instil 4-6 drops into each ear even when only one ear is affected, then fold and gently massage the ear base. Confirm the diagnosis and tympanic membrane integrity before use. Apply the remainder on the back as directed by the label.
Cat Any weight auricular repeat only after veterinary reassessment according to the official instruction
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
12–20 drops
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction.
Cat 1–3 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
1.5 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction.
Cat over 3 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
4–6 drops
For label treatment of otodectosis: clean the pinna and external ear canal, instil 4-6 drops into each ear even when only one ear is affected, then fold and gently massage the ear base. Confirm the diagnosis and tympanic membrane integrity before use. Apply the remainder on the back as directed by the label.
Dog Any weight auricular repeat only after veterinary reassessment according to the official instruction
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
0.5–1 ml
Cut the dropper tip and apply once to dry, intact skin where licking is impossible. For dogs over 50 kg, the label says to add 1 ml for each subsequent 10 kg; that open-ended step is not extrapolated by the calculator. For mange, lice or biting lice, apply 2-3 times at 10-12 day intervals. Repeat against ixodid ticks no more than monthly and against insects no more than every two months. Do not use under 10 weeks, during pregnancy or lactation, with infectious disease or fipronil hypersensitivity. Do not bathe or pet the treated skin for 48 hours.
Dog 1–10 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
1.2–2 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction. For dogs over 50 kg, the label says to add 1 ml for each subsequent 10 kg; the calculator does not extrapolate that open-ended step.
Dog 10–20 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
2.3–3 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction. For dogs over 50 kg, the calculator does not extrapolate the label's open-ended 1 ml per subsequent 10 kg step.
Dog 20–30 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
3.4–4 ml
Apply once to dry, intact skin where licking is impossible. Follow the same repeat limits, contraindications and 48-hour bathing/handling restriction. For dogs over 50 kg, the calculator does not extrapolate the label's open-ended 1 ml per subsequent 10 kg step.
Dog 30–50 kg On the skin once; repeat only as directed by the label
O.L.KAR Rex and Musya drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Rex and Musya drops - current official product instruction
O.L.KAR official veterinary product instruction
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.